Top 3 Biorxiv Papers Today in Pharmacology And Toxicology


2.005 Mikeys
#1. Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics
Ludwig A Hothorn, Felix M. Kluxen, Mario Hasler
Sometimes a re-analysis of toxicological data is useful. However, this usually requires the availability of the original data and in many cases only summary data are available in the publications. Here the generation of pseudo-data under certain assumptions using extension packages in the open-source project R on statistical computing is shown. Several case studies are used to illustrate the applicability in regulatory toxicology.
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biorxivpreprint: Pseudo-data generation allows the statistical re-evaluation of toxicological bioassays based on summary statistics https://t.co/UKvioUVPFh #bioRxiv
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Authors: 3
Total Words: 0
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2.003 Mikeys
#2. Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils
Simon Lind, André Holdfeldt, Jonas Martensson, Martina Sundqvist, Terry P Kenakin, Lena Bjorkman, Huamei Forsman, Claes Dahlgren
The non-activating allosteric modulator AZ1729, specific for free fatty acid receptor 2 (FFA2R), transfers the orthosteric FFA2R agonists propionate and the P2Y2R specific agonist ATP into activating ligands that trigger an assembly of the neutrophil superoxide generating NADPH-oxidase. The homologous priming effect on the propionate response and the heterologous receptor cross-talk sensitized ATP response mediated by AZ1729 are functional characteristics shared with Cmp58, another non-activating allosteric FFA2R modulator. In addition, AZ1729 also turned Cmp58 into a potent activator of the superoxide generating neutrophil NADPH-oxidase, and in agreement with the allosteric modulation concept, the effect was reciprocal in that Cmp58 turned AZ1729 into a potent activating allosteric agonist. The activation signals down-stream of FFA2R when stimulated by the two interdependent allosteric modulators were biased in that, unlike for orthosteric agonists, the two complementary modulators together triggered an activation of the...
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biorxivpreprint: Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils https://t.co/vw6zQE5gFP #bioRxiv
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Authors: 8
Total Words: 12184
Unqiue Words: 2484

1.997 Mikeys
#3. Dalbavancin and wound healing: new evidences/insights in a mouse model of skin infection.
Oriana Simonetti, Guendalina Lucarini, Gianluca Morroni, Fiorenza Orlando, Raffaella Lazzarini, Antonio Zizzi, Lucia Brescini, Mauro Provinciali, Andrea Giacometti, Annamaria Offidani, Oscar Cirioni
Dalbavancin is an effective antibiotic widely used to treat skin infection. Our aim was to determinate the effects of dalbavancin administration on wound healing compared to vancomycin, and to elucidate if EGFR, MMP-1, MMP-9 and VEGF could be involved in its therapeutic mechanism. A mouse model of MRSA skin infection was established. Mice were treated daily with vancomycin (10mg/kg) and weekly with dalbavancin, at day 1 (20 mg/kg) and day 8 (10 mg/kg). After 14 days wounds were excised and bacterial counts were perfomed. Wound healing was assessed by histological and immunohistochemical staining, followed by protein extraction and immunoblotting. Our microbiological results confirmed that both dalbanvancin and vancomycin are effective in reducing the bacterial load in wounds. Dalbavancin had a strong effect compared with infected untreated animals and vancomycin treated group. The wounds treated with dalbavancin showed robust epidermal coverage with a reconstitution of the regular and keratinized epidermal lining and a...
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Authors: 11
Total Words: 7900
Unqiue Words: 3138

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