Top 10 Biorxiv Papers Today in Neuroscience


2.033 Mikeys
#1. The effect of left frontal resection on hand selection: a lesion-tractography study
Henrietta Howells, Guglielmo Puglisi, Antonella Leonetti, Luca Vigano, Luca Fornia, Luciano Simone, Stephanie Forkel, Marco Rossi, Marco Riva, Gabriella Cerri, Lorenzo Bello
Strong right-hand preference on the population level is a uniquely human feature, although the neural basis for this is still not clearly defined. Recent behavioural and neuroimaging literature suggests that hand preference may be related to the orchestrated function and size of fronto-parietal white matter tracts bilaterally. Lesions to these tracts induced during tumour resection may provide an opportunity to test this hypothesis. In the present study, a cohort of seventeen neurosurgical patients with left hemisphere brain tumours were recruited to investigate whether resection of certain white matter tracts affects the choice of hand selected for the execution of a goal-directed task (assembly of jigsaw puzzles). Patients performed the puzzles, but also tests for basic motor ability, selective attention and visuo-constructional ability, preoperatively and one month after surgery. Diffusion tractography of fronto-parietal tracts (the superior longitudinal fasciculus) and the corticospinal tract were performed, to evaluate...
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biorxiv_neursci: The effect of left frontal resection on hand selection: a lesion-tractography study https://t.co/7aATNEZfYD #biorxiv_neursci
biorxivpreprint: The effect of left frontal resection on hand selection: a lesion-tractography study https://t.co/XmlgG7zMEi #bioRxiv
kepkeeloh: RT @biorxiv_neursci: The effect of left frontal resection on hand selection: a lesion-tractography study https://t.co/7aATNEZfYD #biorxiv_…
Guglielmo_Psi: RT @biorxiv_neursci: The effect of left frontal resection on hand selection: a lesion-tractography study https://t.co/7aATNEZfYD #biorxiv_…
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Authors: 11
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2.025 Mikeys
#2. Situating the Left-Lateralized Language Network in the Broader Organization of Multiple Specialized Large-Scale Distributed Networks
Rodrigo M Braga, Lauren M DiNicola, Randy L Buckner
Using procedures optimized to explore network organization within the individual, the topography of a candidate language network was characterized and situated within the broader context of adjacent networks. The candidate network was first identified using functional connectivity and replicated across individuals, datasets, acquisition tasks, and analytic methods. In addition to classical language regions near to perisylvian cortex and temporal pole, additional regions were observed in dorsal posterior cingulate, midcingulate, anterior superior frontal and inferior temporal cortex. The candidate network was selectively activated when processing meaningful (as contrast to non-word) sentences, while spatially adjacent networks showed minimal or even decreased activity. Examined in relation to adjacent networks, the topography of the language network was found to parallel the motif of other association networks including the transmodal association networks linked to theory of mind and episodic remembering (often collectively called...
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biorxiv_neursci: Situating the Left-Lateralized Language Network in the Broader Organization of Multiple Specialized Large-Scale Distributed Networks https://t.co/IQX118QY9n #biorxiv_neursci
biorxivpreprint: Situating the Left-Lateralized Language Network in the Broader Organization of Multiple Specialized Large-Scale Distributed Networks https://t.co/S5PajHhgLl #bioRxiv
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2.025 Mikeys
#3. Sensorimotor neuronal learning requires cortical topography
Aamir Abbasi, Luc Estebanez, Dorian Goueytes, Henri Lassagne, Daniel E. Shulz, Valerie Ego-Stengel
Topographic representations of the peripheral sensory organs are a prominent feature of primary sensory areas in the cerebral cortex. In particular, the whisker representation in the primary somatosensory cortex of rodents is composed of spatially distinct 'barrel' columns, each corresponding to a different whisker on the snout. Although the relationship between the sensory coding properties of neurons and their position in the barrel map has been extensively studied, the functional role of cortical maps remains unclear. We hypothesize that the body map in the primary somatosensory cortex is a framework for the integration of sensory information into motor control. First, we trained head-fixed mice in a cortical closed-loop brain-machine interface task where learning necessitates the integration of sensory feedback. Second, we show that in this task a biomimetic, topographic organization of the sensory feedback is required for learning. Finally, we show that enhanced performance in the biomimetic feedback condition correlates with...
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biorxiv_neursci: Sensorimotor neuronal learning requires cortical topography https://t.co/1rLtt8a1zD #biorxiv_neursci
biorxivpreprint: Sensorimotor neuronal learning requires cortical topography https://t.co/DfaTnAiYYL #bioRxiv
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2.025 Mikeys
#4. Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia
Andre Altmann, David M Cash, Martina Bocchetta, Carolin Heller, Regina H Reynolds, Katrina Moore, Rhian S Convery, David Thomas, John C van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Markus Otto, Mina Ryten, Jonathan D Rohrer, Genetic FTD Initiative, GENFI
Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder characterized by neuronal loss in the frontal and temporal lobes. Despite progress in understanding which genes are associated with the aetiology of FTD (C9orf72, GRN and MAPT), the biological basis of how mutations in these genes lead to cell loss in specific cortical regions remains unclear. In this work we combined gene expression data for 16,912 genes from the Allen Institute for Brain Science atlas with brain maps of gray matter atrophy in symptomatic C9orf72, GRN and MAPT carriers obtained from the Genetic FTD Initiative study. A set of 405 and 250 genes showed significant positive and negative correlation, respectively, with atrophy patterns in all three maps. The gene set with increased expression in spared cortical regions, i.e., signaling regional resilience to atrophy, is enriched for neuronal genes, while the gene set with increased expression in atrophied regions, i.e., signaling regional vulnerability, is enriched for astrocyte genes....
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biorxiv_neursci: Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia https://t.co/r94DNZPVF9 #biorxiv_neursci
biorxivpreprint: Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia https://t.co/10HIEZCT1w #bioRxiv
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Sample Sizes : [6434, 91, 1569, 12082, 10, 12, 25, 144, 186, 674, 5917]
Authors: 36
Total Words: 9134
Unqiue Words: 2893

2.025 Mikeys
#5. Sensitivity to grayscale textures is adapted to natural scene statistics
Tiberiu Tesileanu, Mary M Conte, John J Briguglio, Ann M Hermundstad, Jonathan D Victor, Vijay Balasubramanian
The efficient coding hypothesis posits that sensory circuits and animal behavior should be adapted to the statistical structure of natural signals. Here, we show that the perception of visual textures is adapted to the spatial distribution of light signals at a striking level of detail. We first identify a parametrized 66-dimensional space of grayscale textures defined by local spatial correlations between discrete light intensities. We then devise a method of measuring the contribution of each of these textures to the spatial structure of scenes. Efficient coding predicts that the perceptual salience of a complex sensory signal should be related to its variability in natural settings. Based on an analysis of contrast-equalized natural scenes, this theory predicts that textures involving two-point correlations will be most salient, and it further predicts the relative salience among second-order correlations of different types. We test our predictions by asking observers to locate a briefly-flashed texture strip in a background of...
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biorxiv_neursci: Sensitivity to grayscale textures is adapted to natural scene statistics https://t.co/CSgg7PONmn #biorxiv_neursci
biorxivpreprint: Sensitivity to grayscale textures is adapted to natural scene statistics https://t.co/ARZ4uOqais #bioRxiv
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2.024 Mikeys
#6. Gut microbiome signatures of risk and prodromal markers of Parkinson's disease
Sebastian Heinzel, Velma T.E. Aho, Ulrike Suenkel, Anna-Katharina von Thaler, Claudia Schulte, Christian Deuschle, Sari Hantunen, Kathrin Brockmann, Gerhard W. Eschweiler, Walter Maetzler, Daniela Berg, Petri Auvinen, Filip Scheperjans
Objectives: Alterations of the gut microbiome in Parkinson's disease (PD) have been repeatedly demonstrated. However, little is known about whether such alterations precede disease onset and how they may be related to risk and prodromal markers of PD. We investigated associations of these features with gut microbiome composition. Methods: Established risk and prodromal markers of PD as well as factors related to diet/lifestyle, bowel function and medication were studied in relation to bacterial α-/β-diversity, enterotypes, and taxonomic composition in stool samples of 666 elderly TREND study participants. Results: Among risk and prodromal markers, physical inactivity, constipation and age showed associations with α- and β-diversity, and for both measures subthreshold parkinsonism and physical inactivity showed interaction effects. Moreover, male sex, possible REM-sleep behavior disorder (RBD), smoking as well as body-mass-index, antidiabetic and urate-lowering medication were associated with β-diversity. Physical inactivity and...
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biorxiv_neursci: Gut microbiome signatures of risk and prodromal markers of Parkinson's disease https://t.co/Ycq7Q0xKut #biorxiv_neursci
biorxivpreprint: Gut microbiome signatures of risk and prodromal markers of Parkinson's disease https://t.co/CPJy8SzoG9 #bioRxiv
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2.024 Mikeys
#7. Tracking attention in a visual active paradigm for the diagnosis of disorders of consciousness
Damien Lesenfants, Camille Chatelle, Quentin Noirhomme, Steven Laureys
Background - Clinical assessment of patients with disorders of consciousness (DOC) relies on the clinician's ability to detect a behavioral response to an instruction (e.g., "squeeze my hand"). However, recent studies have shown that some of these patients can produce volitional brain responses to command while no behavioral response is present. This highlights the importance of developing motor-independent diagnostic tool for this population, complementing standardized behavioral evaluation. We here evaluate the ability of a novel gaze-independent attention-based EEG paradigm to detect volitional attentional processes in patients with disorders of consciousness. Methods - Thirty patients with DOC were included in the study: 12 with an unresponsive wakefulness syndrome, 16 in a minimally conscious state (MCS), two who emerged from a MCS. Patients were randomly instructed to either concentrate on a task or rest while brain activity was recorded using EEG during a gaze-independent paradigm. Results - One of two EMCS, one of 16 MCS...
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biorxiv_neursci: Tracking attention in a visual active paradigm for the diagnosis of disorders of consciousness https://t.co/Q3j3NmYLvr #biorxiv_neursci
biorxivpreprint: Tracking attention in a visual active paradigm for the diagnosis of disorders of consciousness https://t.co/KhlN8SeIo1 #bioRxiv
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2.024 Mikeys
#8. Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease
Julia Viard, Yann Loe-Mie, Malik Khelfaoui, Rachel Daudin, Christine Plancon, Anne Boland, Francisco Tejedor, Richard Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valerie Hindie, Henri Blehaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel
Intellectual disability (ID) found in Down syndrome (DS), which is characterized by an extra copy of 234 genes on Chr21 is poorly understood. We first used two DS mouse models that either display an extra copy of the Dyrk1A gene or of the mouse Chr16 syntenic region. Exome sequencing of transcripts deregulated in embryonic hippocampus uncovers enrichment in genes involved in chromatin and synapse respectively. Using large-scale yeast two-hybrid screen (154 distinct screens) of human brain library containing at least 107 independent fragments, we identified 3,636 novel protein-protein interactions with an enrichment of direct interactors of both Chromosome 21(Hsa21) baits and rebounds in ID-related genes. Using proximity ligation assays, we identified that Hsa21-encoded proteins are located at the dendritic spine postsynaptic density in a protein network located at the dendritic spine post synapse. Hsa21 DYRK1A and DSCAM that confers a ~ 20-fold increase in Autism Spectrum Disorders (ASDs) are part of this dendritic spine...
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biorxiv_neursci: Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease https://t.co/feZaIpFIwb #biorxiv_neursci
biorxivpreprint: Chr21 protein-protein interactions: enrichment in products involved in intellectual disabilities, autism and Late Onset Alzheimer Disease https://t.co/HmPVQXLX6L #bioRxiv
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2.015 Mikeys
#9. Context-specific control of the neural dynamics of temporal attention by the human cerebellum
Assaf Breska, Richard B Ivry
Physiological methods have identified a number of signatures of temporal prediction, a core component of attention. While the underlying neural dynamics have been linked to activity within cortico-striatal networks, recent work has shown that the behavioral benefits of temporal prediction causally rely on the cerebellum. Here we examine the involvement of the human cerebellum in the generation and/or temporal adjustment of anticipatory neural dynamics, measuring scalp electroencephalography in individuals with cerebellar degeneration. When the temporal prediction relied on an interval representation, duration-dependent adjustments were impaired in the cerebellar group compared to matched controls. This impairment was evident in ramping activity, beta-band power, and phase locking of delta-band activity. Remarkably, these same neural adjustments were preserved when the prediction relied on a rhythmic stream. Thus, the cerebellum has a context-specific causal role in the adjustment of anticipatory neural dynamics of temporal...
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P_Anastasiades: RT @biorxiv_neursci: Context-specific control of the neural dynamics of temporal attention by the human cerebellum https://t.co/IkBMmoFa7h…
WickmanLab: RT @biorxiv_neursci: Context-specific control of the neural dynamics of temporal attention by the human cerebellum https://t.co/IkBMmoFa7h…
SillitoeLab: RT @biorxiv_neursci: Context-specific control of the neural dynamics of temporal attention by the human cerebellum https://t.co/IkBMmoFa7h…
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2.015 Mikeys
#10. Participation of the rostral anterior cingulate cortex in defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray and contextual fear conditioning
Bruno o Galvão, Alberto Filgueiras, Silvia Maisonnette, Thomas E Krahe, J. Landeira-Fernandez
The rostral anterior cingulate cortex (rACC) is a critical brain structure related to defensive behavior. However, still unclear is whether the rACC also plays a role in defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray (dPAG). In the present study, rats were implanted with electrodes into the dPAG to determine freezing and escape response thresholds after sham or bilateral electrolytic lesions of the rACC. The duration of freezing behavior that outlasted electrical stimulation of the dPAG was also measured. The next day, these animals were subjected to contextual fear conditioning using footshock as an unconditioned stimulus. Lesions of the rACC did not change aversive freezing and escape response thresholds but disrupted post-dPAG stimulation freezing. The lesions also disrupted defensive freezing behavior and analgesia in the formalin test in response to contextual cues previously associated with footshock. These results indicate that the rACC is involved in some but not all aspects of...
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biorxiv_neursci: Participation of the rostral anterior cingulate cortex in defensive behavior induced by electrical stimulation of the dorsal ... https://t.co/Z8yu0ih1lg #biorxiv_neursci
biorxivpreprint: Participation of the rostral anterior cingulate cortex in defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray and contextual fear conditioning https://t.co/6TnqUr94Sq #bioRxiv
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Total Words: 4984
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