Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport
The presence of advection in neuropil is contested and solute transport is claimed to occur by diffusion only. To address this controversy, we implemented a regularized version of the optimal mass transport (rOMT) problem, wherein the advection/diffusion equation is the only a priori assumption required. rOMT analysis with a Lagrangian perspective of glymphatic system (GS) transport revealed that solute speed was faster in cerebrospinal fluid (CSF) compared to grey and white matter. rOMT analysis also demonstrated 2-fold differences in regional particle speed within the brain parenchyma. Collectively, these results imply that advective transport dominates in CSF while diffusion and advection both contribute to transport in parenchyma. In rats with chronic hypertension, solute transport in perivascular spaces (PVS) and PVS-to-tissue transfer was slower compared to normotension. Thus, the analytical framework of rOMT provides novel insights in local variation and dynamics of GS transport that may have implications for neurodegenerative diseases.
NurtureToken New!

Token crowdsale for this paper ends in

Buy Nurture Tokens

Authors

Are you an author of this paper? Check the Twitter handle we have for you is correct.

Sunil Koundal (edit)
Rena Elkin (add twitter)
Saad Nadeem (edit)
Yuechuan Xue (add twitter)
Stefan Constantinou (add twitter)
Simon Sanggaard (add twitter)
Xiaodan Liu (add twitter)
Brittany Monte (add twitter)
Feng Xu (edit)
William Van Nostrand (add twitter)
Maiken Nedergaard (add twitter)
Hedok Lee (add twitter)
Joanna Wardlaw (add twitter)
Helene Benveniste (add twitter)
Allen Tannenbaum (edit)
Category

Physiology

Ask The Authors

Ask the authors of this paper a question or leave a comment.

Read it. Rate it.
#1. Which part of the paper did you read?

#2. The paper contains new data or analyses that is openly accessible?
#3. The conclusion is supported by the data and analyses?
#4. The conclusion is of scientific interest?
#5. The result is likely to lead to future research?

Github
User:
None (add)
Repo:
None (add)
Stargazers:
0
Forks:
0
Open Issues:
0
Network:
0
Subscribers:
0
Language:
None
Youtube
Link:
None (add)
Views:
0
Likes:
0
Dislikes:
0
Favorites:
0
Comments:
0
Other
Sample Sizes (N=):
Inserted:
Words Total:
Words Unique:
Source:
Abstract:
[4, 4, 4, 4, 8, 8, 6, 5, 5, 7, 6, 7, 7, 8, 8]
09/14/19 02:02AM
16,780
4,243
Tweets
biorxiv_physio: Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport https://t.co/6q0EPUbrX8 #biorxiv_physio
biorxivpreprint: Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport https://t.co/4HevwwQMH8 #bioRxiv
Images
Related