XPRESSyourself: Enhancing and Automating the Ribosome Profiling and RNA-Seq Analysis Toolkit
Nucleic acid sequencing is a powerful research tool that has become routine; however, computational bottlenecks hinder many users. XPRESSyourself is a ribosome profiling and RNA-Seq analytical pipeline that aims to eliminate these barriers, standardize in silico protocols, and decrease time-to-discovery. XPRESSyourself additionally introduces tools missing from current ribosome profiling and RNA-Seq toolkits. Using XPRESSyourself to process publicly available ribosome profiling data, we were able to rapidly identify hypothetical mechanisms related to neurodegenerative phenotypes and neuroprotective mechanisms of the small-molecule ISRIB during acute cellular stress, highlighting the ability of XPRESSyourself to rapidly uncover novel biological insight from high-throughput sequence data.
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Jordan A Berg (edit)
Jonathan R Belyeu (add twitter)
Jeffrey T Morgan (add twitter)
Alex J Bott (edit)
Yeyun Ouyang (edit)
Aaron R Quinlan (edit)
Jason Gertz (add twitter)
Jared Rutter (edit)
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Bioinformatics

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07/16/19 11:01AM
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