Spatial and temporal locomotor learning in mouse cerebellum
Stable and efficient locomotion requires precise coordination of whole-body movements. Learned changes in interlimb coordination can be induced by exposure to a split-belt treadmill that imposes different speeds under each side of the body. Here we show that mice adapt to split-belt walking in a way that is remarkably similar to humans, suggesting that this form of locomotor learning is highly conserved across vertebrates. Like human learning, mouse locomotor adaptation is specific to measures of interlimb coordination, has spatial and temporal components that adapt at different rates, and is highly context-specific. Using a variety of approaches, we demonstrate that split-belt adaptation in mice specifically depends on intermediate cerebellum, but is insensitive to large lesions of cerebral cortex. Finally, cell-type specific chemogenetics combined with quantitative behavioral analysis reveal distinct neural circuit mechanisms underlying spatial vs. temporal components of locomotor adaptation.
NurtureToken New!

Token crowdsale for this paper ends in

Buy Nurture Tokens

Authors

Are you an author of this paper? Check the Twitter handle we have for you is correct.

Dana Darmohray (add twitter)
Jovin Jacobs (add twitter)
Hugo G. Marques (add twitter)
Megan R. Carey (edit)
Category

Neuroscience

Ask The Authors

Ask the authors of this paper a question or leave a comment.

Read it. Rate it.
#1. Which part of the paper did you read?

#2. The paper contains new data or analyses that is openly accessible?
#3. The conclusion is supported by the data and analyses?
#4. The conclusion is of scientific interest?
#5. The result is likely to lead to future research?

Github
User:
None (add)
Repo:
None (add)
Stargazers:
0
Forks:
0
Open Issues:
0
Network:
0
Subscribers:
0
Language:
None
Youtube
Link:
None (add)
Views:
0
Likes:
0
Dislikes:
0
Favorites:
0
Comments:
0
Other
Sample Sizes (N=):
Inserted:
Words Total:
Words Unique:
Source:
Abstract:
None
08/10/18 03:21PM
15,351
3,640
Tweets
emilyjanedennis: Preprint of most recent work here https://t.co/sg4RXW24Fv
meganinlisbon: Our second @biorxiv preprint has only been out a few days, but we’re thrilled with the response so far: https://t.co/W16yMLPG9G Honestly, from an author's perspective, it’s quite hard to see the downside. #preprints
gspitz4: RT @biorxiv_neursci: Spatial and temporal locomotor learning in mouse cerebellum https://t.co/nwGfchSB5y #biorxiv_neursci
PromPreprint: Spatial and temporal locomotor learning in mouse cerebellum https://t.co/OW0wr6c99G
bitking69: RT @biorxivpreprint: Spatial and temporal locomotor learning in mouse cerebellum https://t.co/pYfhxAjcyR #bioRxiv
TrackingActions: really beautiful work from @meganinlisbon group! They have a great paradigm for split-belt adaptation in mice, and it's very cool to see the CB vs. cortical dependency - i.e. CB dependent, ctx not (compared to the forelimb reaching task) https://t.co/3kRmQR5N36 https://t.co/pIEYlHIC3t
meganinlisbon: And the preprint is live! Spatial and temporal locomotor learning in mouse cerebellum (aka split-belt treadmill adaptation for mice). We are so excited to finally get this one out there! https://t.co/W16yMLPG9G
Images
Related