Top 1 Biorxiv Papers Today in Synthetic Biology


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#1. Selective germline genome edited pigs and their long immune tolerance in Non Human Primates
Lijin Zou, Youlai Zhang, Ying He, Hui Yu, Jun Chen, Delong Liu, Sixiong Lin, Manman Gao, Gang Zhong, Weicheng Lei, Guangqian Zhou, Xuenong Zou, Kai Li, Yu Yin, Gaofeng Zha, Linxian Li, Yuanlin Zeng, Jianfei Wang, Gang Wang
Organ transplantation is the only curative treatment for patients with terminal organ failure, however, there is a worldwide organ shortage. Genetically modified pig organs and tissues have become an attractive and practical alternative solution for the severe organ shortage, which has been made possible by significant progress in xenotransplantation in recent years. The past several decades witnessed an expanding list of genetically engineered pigs due to technology advancements, however, the necessary combination of genetic modifications in pig for human organ xenotransplantation has not been determined. In the current study, we created a selective germline genome edited pig (SGGEP). The first triple xenoantigens (GGTA, B4GAL, and CAMH) knockout somatic cells were generated to serve as a prototype cells and then human proteins were expressed in the xenoantigen knockout cells, which include human complement system negative regulatory proteins (CD46, CD55, and CD59); human coagulation system negative regulatory proteins...
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biorxivpreprint: Selective germline genome edited pigs and their long immune tolerance in Non Human Primates https://t.co/dx3r6AlifD #bioRxiv
RaviTharakan: RT @biorxivpreprint: Selective germline genome edited pigs and their long immune tolerance in Non Human Primates https://t.co/dx3r6AlifD #…
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