Top 2 Biorxiv Papers Today in Synthetic Biology


2.007 Mikeys
#1. Fundamental Theory of the Evolution Force (FTEF): Gene Engineering utilizing Synthetic Evolution Artificial Intelligence (SYN-AI)
Leroy Keith Davis, Rao M Uppu
The effects of the evolution force are observable in nature at all structural levels ranging from small molecular systems to conversely enormous biospheric systems. However, the evolution force and work associated with formation of biological structures has yet to be described mathematically or theoretically. In addressing the conundrum, we consider evolution from a unique perspective and in doing so we introduce "The fundamental Theory of the Evolution Force". Whereby, the driving force of evolution is defined as a compulsion acting at the matter-energy interface that accomplishes genetic diversity while simultaneously conserving structure and function. By proof of concept, we attempt herein to characterize evolution force associated with genomic building block (GBB) formation utilizing synthetic evolution artificial intelligence (SYN-AI). As part of our methodology, we transform the DNA code into time dependent DNA codes based upon DNA hierarchical structural levels that allow evolution by the exchange of genetic information...
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biorxivpreprint: Fundamental Theory of the Evolution Force (FTEF): Gene Engineering utilizing Synthetic Evolution Artificial Intelligence (SYN-AI) https://t.co/Tyg3dpN6LX #bioRxiv
razoralign: Fundamental Theory of the Evolution Force (FTEF): Gene Engineering utilizing Synthetic Evolution Artificial Intelligence (SYN-AI) https://t.co/rzPnFup5B1
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Sample Sizes : None.
Authors: 2
Total Words: 7562
Unqiue Words: 2063

1.997 Mikeys
#2. Multiplexing cell-cell communication
John T. Sexton, Jeffrey J. Tabor
The engineering of advanced multicellular behaviors, such as the programmed growth of biofilms or tissues, requires cells to communicate multiple aspects of physiological information. Unfortunately, few cell-cell communication systems have been developed for synthetic biology. Here, we engineer a genetically-encoded channel selector device that enables a single communication system to transmit two separate intercellular conversations. Our design comprises multiplexer and demultiplexer sub-circuits constructed from a total of 12 CRISPRi-based transcriptional logic gates, an acyl homoserine lactone-based communication module, and three inducible promoters that enable small molecule control over the conversations. Experimentally-parameterized mathematical models of the sub-components predict the steady state and dynamical performance of the full system. Multiplexed cell-cell communication has applications in synthetic development, metabolic engineering, and other areas requiring the coordination of multiple pathways amongst a...
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biorxivpreprint: Multiplexing cell-cell communication https://t.co/c9ND08nwn7 #bioRxiv
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Sample Sizes : None.
Authors: 2
Total Words: 3994
Unqiue Words: 1657

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