Top 2 Biorxiv Papers Today in Physiology


2.007 Mikeys
#1. Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions
Stephen A Banse, Mark Lucanic, Christine A Sedore, Anna L Coleman-Hulbert, W Todd Plummer, Estabon Chen, Jason L Kish, David Hall, Brian Onken, Michael P Presley, E Grace Jones, Benjamin W Blue, Theo Garrett, Mark Abbott, Jian Xue, Suzhen Guo, Erik Johnson, Anna C Foulger, Manish Chamoli, Ron Falkowski, Ilija Melentijevic, Girish Harinath, Phu Huynh, Shobhna Patel, Daniel Edgar, Cody M Jarrett, Max Guo, Pankaj Kapahi, Gordon J Lithgow, Monica Driscoll, Patrick C Phillips
The goal of the Caenorhabditis Intervention Testing Program is to identify robust and reproducible pro-longevity interventions that are efficacious across genetically diverse cohorts in the Caenorhabditis genus. The project design features multiple experimental replicates collected by three different laboratories. Our initial effort employed fully manual survival assays. With an interest in increasing throughput, we explored automation with flatbed scanner-based Automated Lifespan Machines (ALMs). We used ALMs to measure survivorship of 22 Caenorhabditis strains spanning three species. Additionally, we tested five chemicals that we previously found extended lifespan in manual assays. Overall, we found similar sources of variation among trials for the ALM and our previous manual assays, verifying reproducibility of outcome. Survival assessment was generally consistent between the manual and the ALM assays, although we did observe radically contrasting results for certain compound interventions. We found that particular lifespan...
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biorxivpreprint: Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions https://t.co/vB2aClDt5b #bioRxiv
biorxiv_physio: Automated Lifespan Determination Across Caenorhabditis Strains and Species Reveals Assay-Specific Effects of Chemical Interventions https://t.co/rDlUpoRi73 #biorxiv_physio
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Authors: 31
Total Words: 9646
Unqiue Words: 2638

1.997 Mikeys
#2. Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport
Sunil Koundal, Rena Elkin, Saad Nadeem, Yuechuan Xue, Stefan Constantinou, Simon Sanggaard, Xiaodan Liu, Brittany Monte, Feng Xu, William Van Nostrand, Maiken Nedergaard, Hedok Lee, Joanna Wardlaw, Helene Benveniste, Allen Tannenbaum
The presence of advection in neuropil is contested and solute transport is claimed to occur by diffusion only. To address this controversy, we implemented a regularized version of the optimal mass transport (rOMT) problem, wherein the advection/diffusion equation is the only a priori assumption required. rOMT analysis with a Lagrangian perspective of glymphatic system (GS) transport revealed that solute speed was faster in cerebrospinal fluid (CSF) compared to grey and white matter. rOMT analysis also demonstrated 2-fold differences in regional particle speed within the brain parenchyma. Collectively, these results imply that advective transport dominates in CSF while diffusion and advection both contribute to transport in parenchyma. In rats with chronic hypertension, solute transport in perivascular spaces (PVS) and PVS-to-tissue transfer was slower compared to normotension. Thus, the analytical framework of rOMT provides novel insights in local variation and dynamics of GS transport that may have implications for...
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biorxivpreprint: Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport https://t.co/4HevwwQMH8 #bioRxiv
biorxiv_physio: Glymphatic Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport https://t.co/6q0EPUbrX8 #biorxiv_physio
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Authors: 15
Total Words: 0
Unqiue Words: 0

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