Top 2 Biorxiv Papers Today in Physiology


1.997 Mikeys
#1. Diaphragmatic Central Motor Conduction Changes In Chronic Obstructive Pulmonary Disease
rehab elnemr, Hanaa Shafiek, Rania Sweed
Background and objectives: Respiratory muscles dysfunction has been reported in COPD. Transcranial magnetic stimulation (TMS) is easy non-invasive that has been used for assessing the respiratory corticospinal pathways particularly of diaphragm. We aimed to study the cortico-diaphragmatic motor system changes in COPD using TMS and to correlate the findings with the pulmonary function. Methods: A case control study recruited 30 stable COPD from the out-patient respiratory clinic of Main Alexandria University hospital- Egypt and 17 healthy control subjects who were subjected to spirometry. Cortical conduction of the diaphragm was performed by TMS to all participants followed by cervical magnetic stimulation of the phrenic nerve roots. Diaphragmatic resting motor threshold (DRMT), cortical motor evoked potential latency (CMEPL), CMEP amplitude (CMEPA), peripheral motor evoked potential latency (PMEPL), PMEP amplitude (PMEPA) and central motor conduction time (CMCT) were measured. Results: 66.7% of COPD patients had severe and very...
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biorxivpreprint: Diaphragmatic Central Motor Conduction Changes In Chronic Obstructive Pulmonary Disease https://t.co/F6pvEtOHpt #bioRxiv
biorxiv_physio: Diaphragmatic Central Motor Conduction Changes In Chronic Obstructive Pulmonary Disease https://t.co/qmVocOPwx3 #biorxiv_physio
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Authors: 3
Total Words: 6149
Unqiue Words: 2173

1.975 Mikeys
#2. Gut microbial dysbiosis in individuals with Sjogren's disease
Roberto Mendez, Arjun Watane, Monika Farhangi, Kara M Cavuoto, Tom Leith, Shrish Budree, Anat Galor, Santanu Banerjee
Purpose: To evaluate the gut microbiome in individuals with Sjögrens and correlate bacterial profiles to dry eye (DE) measures. Methods: Prospective case series of individuals with confirmed (n=13) and unconfirmed (n=8) Sjögrens (n=21; cases) as compared to healthy controls (n=10). Stool was analyzed by 16S pyrosequencing and associations between bacterial classes and DE symptoms and signs were examined. Results: Firmicutes was the dominant phylum in the gut, comprising 40-60% of all phyla. On a phyla level, subjects with Sjögrens (confirmed and unconfirmed) had depletion of Firmicutes (1.1- fold) and an expansion of Proteobacteria (3.0-fold), Actinobacteria (1.7-fold), and Bacteroidetes (1.3-fold) compared to controls. Shannon's diversity index showed no differences between groups with respect to the numbers of different OTUs encountered (diversity) and the instances these unique OTUs were sampled (evenness). On the other hand, Faith's phylogenetic diversity showed increased diversity in cases vs controls, which reached...
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Authors: 8
Total Words: 0
Unqiue Words: 0

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