Top 10 Biorxiv Papers Today in Physiology


2.013 Mikeys
#1. Effects of Standing on Spinal Alignment and Lumbar Intervertebral Discs in Young, Healthy Individuals Determined by Positional Magnetic Resonance Imaging
Christian I Weber, Ching-Ting Hwang, Linda R Van Dillen, Simon Y Tang
Traditional diagnostic imaging of the spine is performed in supine, a relatively unloaded position. However, the spine is subjected to complex loading environments in daily activities such as standing. Therefore, we seek to quantify the changes from supine to standing in the spines of young, healthy individuals in standing using a positional MRI system. This is an observational study that examined the changes in the spine and individual intervertebral discs (IVDs) during supine and standing of forty healthy participants (19 males / 21 females) without a history of low back pain. The regional lumbar spinal alignment was measured by the sagittal Cobb angle. Segmental IVD measurements included the segmental Cobb angle, anterior to posterior height (A/P) ratio, and IVD width measured at each L1/L2 - L5/S1 levels. The intra-observer intra-class correlation (ICC) consistency model showed values for measurements ranged from 0.76-0.98. The inter-observer ICC values ranged from 0.68-0.99. The Cobb angle decreased in standing. The L5/S1...
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biorxivpreprint: Effects of Standing on Spinal Alignment and Lumbar Intervertebral Discs in Young, Healthy Individuals Determined by Positional Magnetic Resonance Imaging https://t.co/5bmhOBXYIl #bioRxiv
biorxiv_physio: Effects of Standing on Spinal Alignment and Lumbar Intervertebral Discs in Young, Healthy Individuals Determined by Positional ... https://t.co/Cyw7N3ONGd #biorxiv_physio
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Sample Sizes : None.
Authors: 4
Total Words: 6953
Unqiue Words: 2484

2.001 Mikeys
#2. Respiratory Muscle Training Improves Speech and Pulmonary Function in COPD Patients in a Home Health Setting - a Pilot Study
Nina Bausek, Luzelle Havenga, Sigfredo Aldarondo
Clinical Context and Key Findings: Home-based COPD management, as provided by certified home-health providers, represents a cornerstone of patient care. Respiratory muscle training (RMT) reduces symptoms of COPD and improves underlying respiratory muscle weakness, and may be a beneficial adjunct of standard of care treatment plans. This 4 week pilot study shows that RMT in combination with a standard of care home-based COPD management program can improve pulmonary and speech functions.
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markacarbone: Respiratory Muscle Training Improves Speech and Pulmonary Function in COPD Patients in a Home Health Setting - a Pilot Study https://t.co/voPR01aZZ0
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Sample Sizes : [11, 11]
Authors: 3
Total Words: 3360
Unqiue Words: 1304

1.997 Mikeys
#3. Exercise-stimulated muscle ROS production and glucose uptake requires NADPH oxidase 2
Carlos Henriquez-Olguin, Jonas R. Knudsen, Steffen H. Raun, Zhencheng Li, Emilie Dalbram, Jonas T. Treebak, Lykke Sylow, Rikard Holmdahl, Erik A. Richter, Enrique Jaimovich, Thomas E. Jensen
Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested to stimulate glucose transporter 4 (GLUT4)-dependent glucose transport during artificially evoked contraction ex vivo but whether myocellular ROS production is stimulated by in vivo exercise to control metabolism is unclear. Here, we combined exercise in humans and mice with fluorescent dyes, genetically-encoded biosensors, and NADPH oxidase 2 (NOX2) loss-of-function models to demonstrate that NOX2 is the main source of ROS during moderate-intensity exercise in skeletal muscle. Furthermore, two NOX2 loss-of-function mouse models lacking either p47phox or Rac1 presented striking phenotypic similarities, including greatly reduced exercise-stimulated glucose uptake and GLUT4 translocation. These findings indicate that NOX2 is a major myocellular ROS source regulating glucose transport capacity during moderate intensity exercise.
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DrAJRose: News from @tejensen23 @MuscleBiology: #Exercise-stimulated #muscle #ROS production and #glucose uptake requires #NOX2 https://t.co/v1BGb1EMrC
activescientist: RT @biorxiv_physio: Exercise-stimulated muscle ROS production and glucose uptake requires NADPH oxidase 2 https://t.co/D2GB9ZpaqN #biorxiv…
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Sample Sizes : None.
Authors: 11
Total Words: 7214
Unqiue Words: 2946

1.996 Mikeys
#4. Raman Spectroscopic comparative study of Oxytocin and Freeze-dried Extract of Uvariodendron anisatum Verdeck (Annonaceae) and their influence on diet induced obesity in Sprague Dawley rats
Zephania Birech, Peter W. Mwangi, Prabjot K. Sehmi, Nelly M. Nyaga
Obesity is a condition affecting many people in the world. Obese people have increased risks of developing chronic metabolic diseases such as type II diabetes, hypertension, cancer among others. Early and rapid diagnosis of the condition together with effective treatment is therefore necessary. This work investigated, first, Raman spectroscopic similarities between oxytocin and a freeze-dried extract of a local herbal plant exhibiting oxytocin-like properties called Uvariodendron anisatum Verdeck (Annonaceae) (UAV). Secondly, whether Raman spectroscopy could be used for comparative studies of the influence of oxytocin and UAV on obese Sprague Dawley (SD) rat models. We also wanted to find a Raman biomarker band for obesity or metabolic syndrome. Both oxytocin and extract samples together with blood extracted from the rats were excited using a 785 nm laser after being placed or applied onto a conductive silver paste smeared glass slides and Raman signals collected, recorded and analyzed. The Raman spectroscopic spectral profiles of...
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Authors: 4
Total Words: 5445
Unqiue Words: 2179

0.0 Mikeys
#5. System analysis of the functional cross-talk between PPAR&#945, LXR and FXR in the human HepaRG liver cells
Leonore Wigger, Cristina Casals Casas, Michael Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne
Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous pathways of the intermediate metabolism. The purpose of the present study was to explore in liver cells the interconnectedness between three of them, LXR, FXR, and PPARα, all three known to act on lipid and glucose metabolism, and also on inflammation. The human cell line HepaRG was selected for its best proximity to human primary hepatocytes. Global gene expression of differentiated HepaRG cells was assessed after 4 hours and 24 hours of exposure to GW3965 (LXR agonist), GW7647 (PPARα agonist), and GW4064 and CDCA (FXR synthetic and natural agonist, respectively). Our work revealed that, contrary to our expectations, NR specificity is largely present at the level of target genes, with a smaller than expected overlap of the set of genes targeted by the different NRs. It also highlighted the much broader activity of the synthetic FXR ligand compared to CDCA. More importantly,...
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Authors: 7
Total Words: 8516
Unqiue Words: 2737

0.0 Mikeys
#6. Investigation of the transcriptional profile of human kidneys during machine perfusion reveals potential benefits of haemoadsorption
John Robert Ferdinand, Sarah A Hosgood, Tom Moore, Christopher J Ward, Tomas Castro Dopico, Michael L Nicholson, Menna R Clatworthy
Transplantation is the optimal treatment for most patients with end stage kidney disease but organ shortage is a major challenge. Normothermic machine perfusion (NMP) has been used to re-condition marginal organs but the mechanisms by which NMP might benefit transplant kidneys are not fully understood. Furthermore, the question of whether removal of pro-inflammatory mediators from the perfusate might offer additional benefits in optimising kidneys prior to transplantation has not been addressed. Using pairs of human kidneys obtained from the same donor, we compared the effect of NMP with that of cold storage on the global transcriptome of kidneys, and then went on to investigate the impact of adding a haemoadsorption device to the NMP circuit. We found that cold storage significantly reduced the expression of inflammatory genes, but also of genes required for energy generation such as those encoding oxidative phosphorylation (OXPHOS) enzymes. In contrast, during NMP, there was marked upregulation OXPHOS genes, as well as a number...
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drbstewart: https://t.co/VxEBrlEgm7 Terrific data on bioarxiv from John-in-the-lab et al. from @ClatworthyLab "The use of a haemoadsorber (HA) during machine perfusion reduces inflammatory gene expression and increases OXphos, with potential benefits for kidney transplantation." https://t.co/fpJoYIgS9B
ESOTtransplant: RT @drbstewart: https://t.co/VxEBrlEgm7 Terrific data on bioarxiv from John-in-the-lab et al. from @ClatworthyLab "The use of a haemoadsor…
mnaesens: RT @drbstewart: https://t.co/VxEBrlEgm7 Terrific data on bioarxiv from John-in-the-lab et al. from @ClatworthyLab "The use of a haemoadsor…
loudon_kevin: RT @drbstewart: https://t.co/VxEBrlEgm7 Terrific data on bioarxiv from John-in-the-lab et al. from @ClatworthyLab "The use of a haemoadsor…
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Sample Sizes : [4, 10, 1794, 898, 4026, 2606, 1702]
Authors: 7
Total Words: 10013
Unqiue Words: 2404

0.0 Mikeys
#7. Antlions are sensitive to subnanometer amplitude vibrations carried by sand substrates
Vanessa Martinez, Elise Nowbahari, David Sillam-Dussès, Vincent Lorent
European pit-building antlions (Myrmeleon inconspicuus / Rambur 1842) are studied in their capacity to detect vibrations generated by the locomotion of an ant (Cataglyphis cursor) outside the pit. These locomotions have been recorded by laser ve- locimetry and copied in detail in their time sequences. The sequences are replicated by micro-controllers digital outputs acting on piezoelectric transducers placed several centimeters outside the peripheries of the pits: their actions on the surface of a sand media create surface waves with particle accelerations that are 3 orders of magnitude less than g, alleviating any possibility of sand avalanche towards the bottom of the pit. Depending on the amplitude of the vibrations, the antlions answer back, generally by sand tossing. One remarkable feature is the time delay from the start of the cue and the aggressive behavior induced by this cue. This time delay is studied versus the cue amplitude. The result of this work is that anlions answer back within minutes to cues with amplitudes...
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Sample Sizes : None.
Authors: 4
Total Words: 6399
Unqiue Words: 2146

0.0 Mikeys
#8. Arrhythmia Mechanisms and Spontaneous Calcium Release: II – From Calcium Spark to Re-entry and Back
Michael A. Colman
Motivation The role of sub-cellular spontaneous calcium release events (SCRE) in the development of arrhythmia associated with atrial and ventricular tachycardia and fibrillation has yet to be investigated in detail. SCRE may underlie the emergence of spontaneous excitation in single cells, resulting in arrhythmic triggers in tissue. Furthermore, they can promote the substrate for conduction abnormalities. However, the potential interactions with re-entrant excitation have yet to be explored. The primary aim of this study was therefore to apply a novel computational approach to understand the multi-scale coupling between re-entrant excitation and SCRE. Methods A general implementation of Spontaneous Release Functions – which reproduce the calcium dependent SCRE dynamics of detailed cell models at a significantly reduced computational cost – was used to reproduce SCRE in tissue models. Arrhythmic dynamics, such as rapid pacing and re-entry, were induced in the tissue models and the resulting interactions with SCRE were analysed....
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Authors: 1
Total Words: 9833
Unqiue Words: 2116

0.0 Mikeys
#9. Pain sensitivity and athletic performance
lior zeller, Nadav Shimoni, Alina Vodonos, Iftach Sagy, Leonid Barski, Dan Buskila
Purpese: To determine whether higher pain thresholds are associated with better performance in long-distance runners. Design: Cross-sectional study. Methods: Seventy participants, divided into groups of fast and non-fast runners according to peak results in a 10km run. Main Outcome Measures, Cold pressor test. Results: Of the 70 subjects, 28 were in the fastest group (less than 39 minutes in a 10km run) and 42 in the non-fast group. The faster group was characterized with older age (34.0±8.5 vs. 29.5±5.7, p=0.01), greater mean weekly running time (5.5 (0-17) vs. 2 (0-10), p<0.001), and more years of running [10 (1.5-34.0) vs. 7 (0-20, p=0.05)]. In a multivariable analysis longer cold pressor time was associated with faster 10Km run (O.R 1.01, 95% C.I 1.00-1.01). Conclusions: It seems that higher pain thresholds play an important role in the superior ability of long distance runners.
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DoroThuillier: Pain sensitivity and athletic performance https://t.co/XKb1GZUqt2
activescientist: RT @biorxiv_physio: Pain sensitivity and athletic performance https://t.co/UsNR0qm4Zm #biorxiv_physio
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Sample Sizes : [28, 42]
Authors: 6
Total Words: 4146
Unqiue Words: 1533

0.0 Mikeys
#10. Optical determination of absolute membrane potential
Julia R. Lazzari-Dean, Anneliese M.M. Gest, Evan Miller
All cells maintain ionic gradients across their plasma membranes, producing transmembrane potentials (Vmem). Mounting evidence suggests a relationship between resting Vmem and the physiology of non-excitable cells with implications in diverse areas, including cancer, cellular differentiation, and body patterning. A lack of non-invasive methods to record absolute Vmem limits our understanding of this fundamental signal. To address this need, we developed a fluorescence lifetime-based approach (VF-FLIM) to visualize and optically quantify Vmem with single-cell resolution. Using VF-FLIM, we report Vmem distributions over thousands of cells, a 100-fold improvement relative to electrophysiological approaches. In human carcinoma cells, we visualize the voltage response to epidermal growth factor stimulation, stably recording a 10-15 mV hyperpolarization over minutes. Using pharmacological inhibitors, we identify the source of the hyperpolarization as the Ca2+-activated K+ channel KCa3.1. The ability to optically quantify absolute Vmem...
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MillerChemBio: I'm very pleased to share our lab's first @biorxivpreprint preprint: Optical determination of absolute membrane potential, lead by two talented students, @JLazzariDean and Anneliese. Take a look here: https://t.co/qFKUiuWQVx or on our lab's website: https://t.co/dSLEjIgljO
StevenC_Boggess: Congrats to my talented coworkers Julia and Anneliese on their recent submission to @biorxivpreprint ! @MillerChemBio Optical determination of absolute membrane potential https://t.co/7qfMLOwdVo
BalintZKacsoh: RT @biorxivpreprint: Optical determination of absolute membrane potential https://t.co/Aj7aTIDmgS #bioRxiv
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Sample Sizes : [17, 17, 2, 1056, 368, 2410, 1310]
Authors: 3
Total Words: 20458
Unqiue Words: 5400

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