Top 3 Biorxiv Papers Today in Physiology


2.008 Mikeys
#1. Negative calorie foods: An empirical examination of what is fact or fiction
Katherine M Buddemeyer, Ashley E Alexander, Stephen M Secor
A proposed weight loss strategy is to include in ones diet foods that are deemed negative calorie. In theory, negative-calorie foods are foods for which more energy is expended in their digestion and assimilation than is consumed, thereby resulting in an energy deficit. Negative calorie foods are characterized by a high water and fiber content and little fat. Although the existence of negative calorie foods has been debated, there is no empirical study that has fully addressed the validity of foods being negative calorie. We conducted such a study using the omnivorous bearded dragon ( Pogona vitticeps ) and celery as the tested food due to its high fiber and low caloric content. Following their consumption of celery meals equaling in mass to 5% of body mass, we measured each lizards postprandial metabolic rates to calculate specific dynamic action (SDA). Feces and urate were collected after meals to determine the energy lost to excretion. The specific energy of the celery meals, feces, and urate was determined by bomb calorimetry....
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biorxivpreprint: Negative calorie foods: An empirical examination of what is fact or fiction https://t.co/bt8EUJvhMD #bioRxiv
biorxiv_physio: Negative calorie foods: An empirical examination of what is fact or fiction https://t.co/oRgAkCRerE #biorxiv_physio
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Total Words: 8492
Unqiue Words: 2997

1.992 Mikeys
#2. An high dose of a conjugated linoleic acid increases fatty liver and insulin resistance in lactating mice
liqiang HAN, Kun Pang
This study aimed to evaluate the effect of a high dose of conjugated linoleic acid (CLA) on lactating mice. In experiment one, KUNMING mice were separated into four groups (n = 6 per group); the control (CON) group received 3.0% linoleic acid oil (LA), the L-CLA group received 1.0% LA and 2.0% CLA mixture, the M-CLA group received 2.0% LA and 1.0% CLA mixture, and the H-CLA group received 3.0% CLA mixture. Feeding proceeded from day 4 to day 10 during lactation. In experiment two, the CON group received 2.0% LA and the H-CLA group received 2.0% CLA. Blood parameters were analysed for all groups, and insulin tolerance tests (ITTs) were conducted. CLA treatment did not affect the dam weight, but it significantly decreased the food intake of dams. Furthermore, CLA decreased the weight of pups, which was attributed to lower milk fat. H-CLA group mice displayed increased liver weight and liver triglyceride content, as well as a higher TG content and I3-GT activity in blood. Moreover, a high dose of CLA resulted in insulin resistance,...
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1.91 Mikeys
#3. Evaluating Muscle Fiber Contractility and the Transcriptome, Proteome, Metabolome, and Lipidome of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy
Douglas W Van Pelt, Yalda A Kharaz, Dylan C Sarver, Logan R Eckhardt, Justin T Dzierzawski, Nathaniel P Disser, Alex N Piacentini, Eithne Comerford, Brian McDonagh, Christopher L Mendias
Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease characterized by extensive muscle weakness and eventual complete tetraplegia. The mdx mouse strain, which lacks a functional dystrophin protein, is the most frequently used small animal model in dystrophy research, but has limited pathological changes compared to patients with DMD. The mdx/mTR mouse strain, that lacks functional dystrophin and has depleted pools of muscle stem cells, is an emerging model of DMD. Previous reports have identified accelerated degeneration in mdx/mTR mice compared to mdx mice, but mdx/mTR mice have not been as extensively phenotyped. Therefore, to gain a greater understanding of the pathological changes present the mdx/mTR strain, we measured contractility of muscle fibers, and evaluated changes in the transcriptome with RNA sequencing, and in the proteome, metabolome, and lipidome using untargeted mass spectroscopy. The hindlimb muscles of four month old male wild type (WT) C57Bl/6 and mdx/mTR mice were used for analysis. We...
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