Top 2 Biorxiv Papers Today in Pathology


2.003 Mikeys
#1. Characterization of OA development between sexes in the rat medial meniscal transection model
Krishna Pucha, Jay M McKinney, Julia M Fuller, Nick J Willett
Objective: Osteoarthritis (OA) is a chronic degenerative disease of the joints characterized by articular cartilage degradation. While there are clear sex differences in OA development in humans, most pre-clinical research has been conducted solely in male animals thus limiting the ability of these findings to be generalized to both sexes in the context of this disease. The objective of this study was to determine if sex impacts the progression and severity of OA in the rat medial meniscal tear (MMT) preclinical animal model used to surgically induce OA. It was hypothesized that differences would be observed between males and females following MMT surgery. Design: A MMT model was employed in male and female Lewis rats to induce OA. Animals were euthanized 3 weeks post-surgery and EPIC-μCT was used to quantitatively evaluate articular cartilage structure and composition, osteophyte volumes and subchondral bone structure. Results: Quantitative analysis of the medial 1/3 articular cartilage via EPIC-μCT showed increased cartilage...
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biorxivpreprint: Characterization of OA development between sexes in the rat medial meniscal transection model https://t.co/sZCFJernHd #bioRxiv
WillettLabs: Our latest @biorxivpreprint just posted -- Comparing OA development in male and female rats using the standard MMT model. Study led by our amazing undergrad Ananthu Pucha! https://t.co/ZYKtB6bT6K #bioRxiv https://t.co/Hb2mf3vd8v
FunToNuntu: RT @biorxivpreprint: Characterization of OA development between sexes in the rat medial meniscal transection model https://t.co/sZCFJernHd…
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Sample Sizes : [16, 15]
Authors: 4
Total Words: 7056
Unqiue Words: 1876

1.998 Mikeys
#2. Alzheimer's genetic risk factor FERMT2 (Kindlin-2) is regulated by risk allele-binding of miR-4504 and leads to synaptic dysfunction in an APP-dependent manner
Fanny Eysert, Audrey Coulon, Emmanuelle Boscher, Anais-Camille Vreulx, Amandine Flaig, Tiago Mendes, Sandrine Hughes, Benjamin Grenier-Boley, Xavier Hanoulle, Florie Demiautte, Mikael Marttinen, Mari Takalo, Philippe Amouyel, Shruti Desai, Ian Pike, Mikko Hiltunen, Melissa Farinelli, Charlotte Delay, Nicolas Malmanche, Sébastien Hébert, Julie Dumont, Devrim Kilinc, Jean-Charles Lambert, Julien Chapuis
The pathophysiological roles of Alzheimer's disease (AD) genetic risk factors are often unknown. In this study, we show that FERMT2 (or Kindlin-2) downregulation by miRNAs modulates APP metabolism leading to increased Aβ secretion. In particular, miR-4504, overexpressed in AD brains, downregulates FERMT2 expression as a function of rs7143400 T allele, associated with an increased AD risk. Decreased FERMT2 appears to be deleterious through altering both axonal growth and long-term potentiation in an APP-dependent manner. Overall, this work provides important mechanistic insight on how risk variants may influence AD pathogenesis and reinforces the roles of FERMT2 and miRNAs in Aβ/APP biology.
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biorxivpreprint: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) is regulated by risk allele-binding of miR-4504 and leads to synaptic dysfunction in an APP-dependent manner https://t.co/xXZKoWDLac #bioRxiv
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Authors: 24
Total Words: 0
Unqiue Words: 0

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