Top 10 Biorxiv Papers Today in Neuroscience


2.04 Mikeys
#1. Inter-subject pattern analysis: a straightforward and powerful scheme for group-level MVPA.
Qi Wang, Bastien Cagna, Thierry Chaminade, Sylvain Takerkart
Multivariate pattern analysis (MVPA) has become vastly popular for analyzing functional neuroimaging data. At the group level, two main strategies are used in the literature. The standard one is hierarchical, combining the outcomes of within-subject decoding results in a second-level analysis. The alternative one, inter-subject pattern analysis, directly works at the group-level by using, e.g, a leave-one-subject-out cross-validation. This study provides a thorough comparison of these two group-level decoding schemes, using both a large number of artificial datasets where the size of the multivariate effect and the amount of inter-individual variability are parametrically controlled, as well as two real fMRI datasets comprising respectively 15 and 39 subjects. We show that these two strategies uncover distinct significant regions with partial overlap, and that inter-subject pattern analysis is able to detect smaller effects and to facilitate the interpretation. The core source code and data are openly available, allowing to fully...
more | pdf
Figures
Tweets
biorxivpreprint: Inter-subject pattern analysis: a straightforward and powerful scheme for group-level MVPA. https://t.co/oYEAa9n0xV #bioRxiv
biorxiv_neursci: Inter-subject pattern analysis: a straightforward and powerful scheme for group-level MVPA. https://t.co/rEOxmJtopD #biorxiv_neursci
josepemanzano: RT @biorxiv_neursci: Inter-subject pattern analysis: a straightforward and powerful scheme for group-level MVPA. https://t.co/rEOxmJtopD #…
zuxfoucault: RT @biorxiv_neursci: Inter-subject pattern analysis: a straightforward and powerful scheme for group-level MVPA. https://t.co/rEOxmJtopD #…
Github

A set of scripts demonstrating Inter-Subject Pattern Analysis (ISPA) for functional MRI data

Repository: inter_subject_pattern_analysis
User: SylvainTakerkart
Language: Python
Stargazers: 0
Subscribers: 1
Forks: 0
Open Issues: 0
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 4
Total Words: 9415
Unqiue Words: 2401

2.038 Mikeys
#2. Modulation of visual cortex by hippocampal signals
Julien Fournier, Aman B Saleem, Efthymia Mika Diamanti, Miles J Wells, Kenneth D Harris, Matteo Carandini
Neurons in primary visual cortex (V1) are influenced by the animal's position in the environment and encode positions that correlate with those encoded by hippocampus (CA1). Might V1's encoding of spatial positions be inherited from hippocampal regions? If so, it should depend on non-visual factors that affect the encoding of position in hippocampus, such as the physical distance traveled and the phase of theta oscillations. We recorded V1 and CA1 neurons while mice ran through a virtual corridor and confirmed these predictions. Spatial representations in V1 and CA1 were correlated even in the absence of visual cues. Moreover, similar to CA1 place cells, the spatial responses of V1 neurons were influenced by the physical distance traveled and the phase of hippocampal theta oscillations. These results reveal a modulation of cortical sensory processing by non-sensory estimates of position that might originate in hippocampal regions.
more | pdf
Figures
Tweets
biorxivpreprint: Modulation of visual cortex by hippocampal signals https://t.co/u244EENxhp #bioRxiv
biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
JakeJordan8: The hippocampus may contribute spatial information to V1 https://t.co/ig4n9k3qPn
PromPreprint: Modulation of visual cortex by hippocampal signals https://t.co/YXPfZD1thG
CUBRICcardiff: RT @biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
PhilCorlett1: RT @biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
ABurgalossi: RT @biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
JonPShine: RT @biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
estef_azevedo: RT @JakeJordan8: The hippocampus may contribute spatial information to V1 https://t.co/ig4n9k3qPn
Sandra_RoPi: RT @biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
tanya_wen: RT @biorxiv_neursci: Modulation of visual cortex by hippocampal signals https://t.co/fLhexH1gmd #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 6
Total Words: 11155
Unqiue Words: 2546

2.031 Mikeys
#3. Enriching hippocampal memory function in older adults through video games
Gregory D Clemenson, Shauna M Stark, Samantha M Rutledge, Craig EL Stark
Healthy aging is accompanied by a steady cognitive decline with clear losses in memory. Animal studies have consistently demonstrated that simply modifying an animal's living environment (known as environmental enrichment) can have a positive influence on age-related cognitive decline in the hippocampus. Previously, we showed that playing immersive 3D video games can improve hippocampal-based memory in young healthy adults, suggesting that the exploration of the large open worlds of modern-day video games may act as proxy for environmental enrichment in humans. Here, we replicated our previous video game study in older adults and showing that playing video games for 4 weeks can improve hippocampal-based memory in a population that is already experiencing age-related decline in this memory. Furthermore, we showed that the improvements last for up to 4 weeks past the intervention, highlighting the potential of video games as intervention for age-related cognitive decline.
more | pdf
Figures
Tweets
biorxivpreprint: Enriching hippocampal memory function in older adults through video games https://t.co/fcKYRmHuAm #bioRxiv
biorxiv_neursci: Enriching hippocampal memory function in older adults through video games https://t.co/aZIpbT595Q #biorxiv_neursci
jsnsndr: RT @biorxiv_neursci: Enriching hippocampal memory function in older adults through video games https://t.co/aZIpbT595Q #biorxiv_neursci
MindfulRat: RT @biorxiv_neursci: Enriching hippocampal memory function in older adults through video games https://t.co/aZIpbT595Q #biorxiv_neursci
JonPShine: RT @biorxiv_neursci: Enriching hippocampal memory function in older adults through video games https://t.co/aZIpbT595Q #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 4
Total Words: 6524
Unqiue Words: 1976

2.02 Mikeys
#4. Co-localization of pain and reduced intra-epidermal nerve fibre density in individuals with HIV-associated sensory neuropathy
Imraan G Patel, Peter Kamerman
We investigated, in individuals with HIV-associated sensory neuropathy (HIV-SN), whether having pain at the ankle skin biopsy site was associated with lower intra-epidermal nerve fibre density (IENFD) compared to not having pain at the ankle biopsy site. We recruited 15 individuals with symptomatic HIV-SN. Nine participants had pain at the site where the ankle biopsy was taken, while six participants had no pain at all (n = 2) or had pain that was localised to the feet only (n = 4). Skin punch biopsies were taken from the ankle and the thigh. Biopsies were processed and IENFD quantified using standard protocols. Contrasts between the two groups were made using the overlap of confidence interval (CI) method. We found that IENFD was substantially lower in the group that had pain at the site of the ankle biopsy compared to the other group [6.6 (CI: 5.3 to 7.2) vs. 3.3 (CI: 10.0 to 15.0) fibres/mm]. However, there was no group differences at the thigh biopsy site [15.6 (CI: 15.0 to 15.9) vs 16.2 (CI: 14.5 to 17.8) fibres/mm]. When...
more | pdf
Figures
Tweets
biorxivpreprint: Co-localization of pain and reduced intra-epidermal nerve fibre density in individuals with HIV-associated sensory neuropathy https://t.co/al5oKvEK9n #bioRxiv
biorxiv_neursci: Co-localization of pain and reduced intra-epidermal nerve fibre density in individuals with HIV-associated sensory neuropathy https://t.co/XIqV885rHe #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 2
Total Words: 3272
Unqiue Words: 1166

2.019 Mikeys
#5. Do questionnaires reflect their purported cognitive functions?
Ian A Clark, Eleanor A Maguire
Questionnaires are used widely across psychology and permit valuable insights into a person's thoughts and beliefs, which are difficult to derive from objective measures alone. Given their importance and widespread use, it is vital that questionnaires map onto the cognitive functions they purport to reflect. However, where performance on naturalistic tasks such as imagination, autobiographical memory, future thinking and navigation, is concerned, there is a dearth of knowledge about the relationship between objective and subjective measures. Questionnaires are also typically designed to probe a specific aspect of cognition, when researchers sometimes want to obtain a broad profile of a participant. To the best of our knowledge, no questionnaire exists that asks simple single questions about a range of cognitive functions. To address these gaps in the literature, we recruited a large sample of participants (n = 217), all of whom completed a battery of widely used questionnaires and performed ecological tasks involving imagination,...
more | pdf
Figures
Tweets
biorxivpreprint: Do questionnaires reflect their purported cognitive functions? https://t.co/72qPCk2Bei #bioRxiv
biorxiv_neursci: Do questionnaires reflect their purported cognitive functions? https://t.co/mCX9ptWnlk #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 2
Total Words: 25904
Unqiue Words: 4069

2.019 Mikeys
#6. Stringent structural plasticity of dendritic spines revealed by two-photon glutamate uncaging in adult mouse neocortex in vivo
Jun Noguchi, Akira Nagaoka, Tatsuya Hayama, Hasan Ucar, Sho Yagishita, Noriko Takahashi, Haruo Kasai
Two-photon uncaging of glutamate has been widely utilized to characterize the structural plasticity in brain slice preparations in vitro. Here, we investigated, for the first time, the spine plasticity using glutamate uncaging in the neocortex of adult mice in vivo. The spine enlargement was induced in a smaller fraction (22%) of spines than in the young hippocampal slices (95%) even under a low magnesium condition. Once induced, the time-course and the mean amplitudes (81%) of long-term enlargement were much the same as those in slices. Low frequency (1-2 Hz) glutamate uncaging resulted in spine shrinkage in a similar fraction (34%) of spines as in vitro, but spread to the neighboring spines to a less degree than in vitro. Thus, we have found that the adult neocortex in vivo shows similar plasticity of spines as in young hippocampus in vitro, while only a smaller subset of spines show rapid enlargement.
more | pdf
Figures
Tweets
biorxivpreprint: Stringent structural plasticity of dendritic spines revealed by two-photon glutamate uncaging in adult mouse neocortex in vivo https://t.co/LbpkSe0xmZ #bioRxiv
biorxiv_neursci: Stringent structural plasticity of dendritic spines revealed by two-photon glutamate uncaging in adult mouse neocortex in vivo https://t.co/f6U7liWT2F #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 7
Total Words: 7826
Unqiue Words: 2413

2.018 Mikeys
#7. Characterization of pathology-inducing α-synuclein species from human diseased brain tissue
John D Graef, Nina Hoque, Craig Polson, Ling Yang, Lawrence Iben, Yang Cao, Nino Devidze, Michael K Ahlijanian, Jere Meredith
Synucleinopathies are a group of neurodegenerative diseases characterized by the presence of pathological accumulations of misfolded, phosphorylated α-synuclein (αSyn) protein. Multiple lines of evidence indicate that synucleinopathy disease progression is driven by a prion-like process of transmission of a pathologic form of αSyn. One potential therapeutic approach to prevent cell-to-cell propagation is to target this transmissible species with selective antibodies. In this study, a rodent primary neuronal culture reporter system was developed to monitor induction of detergent-insoluble, phosphorylated (pS129) aggregates of αSyn. Induction of pS129 αSyn pathology was observed with both synthetic αSyn fibrils (PFFs) and brain lysates from multiple system atrophy (MSA) patients but not αSyn monomers or human brain lysate controls. The induction-competent species in MSA lysates could be enriched by high-speed centrifugation suggesting that it is present as a high molecular weight aggregate. Furthermore, samples derived from brain...
more | pdf
Figures
Tweets
biorxivpreprint: Characterization of pathology-inducing α-synuclein species from human diseased brain tissue https://t.co/71LJGSLp0E #bioRxiv
biorxiv_neursci: Characterization of pathology-inducing α-synuclein species from human diseased brain tissue https://t.co/b0zwBvEXyY #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 9
Total Words: 10915
Unqiue Words: 2681

2.012 Mikeys
#8. The effects of cerebellar transcranial direct current stimulation on the cognitive stage of sequence learning
Hannah K. Ballard, James R.M. Goen, Ted Maldonado, Jessica A. Bernard
Though the cerebellum has been previously implicated in explicit sequence learning, the exact role of this structure in the acquisition of motor skills is not completely clear. The cerebellum contributes to both motor and non-motor behavior. Thus, this structure may contribute not only to the motoric aspects of sequence learning, but may also play a role in the cognitive components of these learning paradigms. Therefore, we investigated the consequence of both disrupting and facilitating cerebellar function using high definition transcranial direct current stimulation (HD-tDCS) prior to the completion of an explicit motor sequence learning paradigm. Using a mixed within- and between-subjects design, we employed cathodal (n=21) and anodal (n=23) tDCS (relative to sham), targeting the lateral posterior cerebellum, to temporarily modulate function and investigate the resulting effects on the acquisition of a sequential pattern of finger movements. Results indicate that cathodal stimulation has a positive influence on learning while...
more | pdf
Figures
None.
Tweets
biorxivpreprint: The effects of cerebellar transcranial direct current stimulation on the cognitive stage of sequence learning https://t.co/Nebd4qGAyv #bioRxiv
biorxiv_neursci: The effects of cerebellar transcranial direct current stimulation on the cognitive stage of sequence learning https://t.co/7vfdZqKo5U #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 4
Total Words: 0
Unqiue Words: 0

2.01 Mikeys
#9. On the relationship between LFP beta oscillation amplitude and firing rate of individual neurons in monkey motor cortex
Joachim Confais, Nicole Malfait, Thomas Brochier, Alexa Riehle, Bjørg Elisabeth Kilavik
Beta oscillations are prominent in motor cortical local field potentials (LFPs), and their relationship to the local neuronal spiking activity has been extensively studied. Many studies have shown that in motor cortex, spikes of individual neurons tend to lock to the phase of LFP beta oscillations. However, there are contradictory results concerning whether there is also an intrinsic relationship between the amplitude of LFP beta oscillations and the firing rate of individual neurons. To resolve this controversial issue, we correlated the LFP beta oscillation amplitude recorded in macaque motor cortex with spike counts of individual neurons during visuomotor behavior, in two different manners. First, in an analysis termed task-related correlation, we included data obtained across all behavioral task epochs. These task-related correlations were frequently significant, and of either negative or positive sign. Second, in an analysis termed trial-by-trial correlation, we included only data from a well-defined steady-state pre-cue...
more | pdf
Figures
Tweets
biorxivpreprint: On the relationship between LFP beta oscillation amplitude and firing rate of individual neurons in monkey motor cortex https://t.co/9XE6R9J677 #bioRxiv
biorxiv_neursci: On the relationship between LFP beta oscillation amplitude and firing rate of individual neurons in monkey motor cortex https://t.co/TPMnHbJDcb #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : None.
Authors: 5
Total Words: 13270
Unqiue Words: 2839

2.01 Mikeys
#10. Anatomo-functional correlates of auditory development in infancy
Parvaneh Adibpour, Jessica Lebenberg, Claire Kabdebon, Ghislaine Dehaene-Lambertz, Jessica Dubois
Brain development incorporates several intermingled mechanisms throughout infancy leading to intense and asynchronous maturation across cerebral networks and functional modalities. Combining electroencephalography (EEG) and diffusion magnetic resonance imaging (MRI), previous studies in the visual modality showed that the functional maturation of the event-related potentials (ERP) during the first postnatal semester relates to structural changes in the corresponding white matter pathways. Here we aimed to investigate similar issues in the auditory modality. We measured ERPs to syllables in 1- to 6-month-old infants and analyzed them in relation with the maturational properties of underlying neural substrates measured with diffusion tensor imaging (DTI). We first observed a decrease in the latency of the auditory P2, and a decrease of diffusivities in the auditory tracts and perisylvian regions with age. Secondly, we highlighted some of the early functional and structural substrates of lateralization. Contralateral responses to...
more | pdf
Figures
Tweets
biorxivpreprint: Anatomo-functional correlates of auditory development in infancy https://t.co/TCugCgERLa #bioRxiv
biorxiv_neursci: Anatomo-functional correlates of auditory development in infancy https://t.co/BoUs8rUx1w #biorxiv_neursci
Github
None.
Youtube
None.
Other stats
Sample Sizes : [16, 15, 23, 19, 22, 21, 22, 22, 21, 16, 15, 16, 15]
Authors: 5
Total Words: 12945
Unqiue Words: 3049

About

Assert is a website where the best academic papers on arXiv (computer science, math, physics), bioRxiv (biology), BITSS (reproducibility), EarthArXiv (earth science), engrXiv (engineering), LawArXiv (law), PsyArXiv (psychology), SocArXiv (social science), and SportRxiv (sport research) bubble to the top each day.

Papers are scored (in real-time) based on how verifiable they are (as determined by their Github repos) and how interesting they are (based on Twitter).

To see top papers, follow us on twitter @assertpub_ (arXiv), @assert_pub (bioRxiv), and @assertpub_dev (everything else).

To see beautiful figures extracted from papers, follow us on Instagram.

Tracking 100,376 papers.

Search
Sort results based on if they are interesting or reproducible.
Interesting
Reproducible
Feedback
Online
Stats
Tracking 100,376 papers.