Top 3 Biorxiv Papers Today in Immunology


2.023 Mikeys
#1. Dietary intake regulates the circulating inflammatory monocyte pool
Stefan Jordan, Navpreet Tung, Maria Casanova-Acebes, Christie Chang, Claudia Cantoni, Dachuan Zhang, Theresa H. Wirtz, Shruti Naik, Samuel A. Rose, Chad N. Brocker, Anastasiia Gainullina, Barbara B. Maier, Derek LeRoith, Frank J. Gonzalez, Felix Meissner, Jordi Ochando, Adeeb Rahman, Jerry E. Chipuk, Maxim N. Artyomov, Paul S. Frenette, Laura Piccio, Marie-Luise Berres, Emily J. Gallagher, Miriam Merad
Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes. Regulation of peripheral monocyte numbers was dependent on dietary glucose and protein levels. Specifically, we found that activation of the low-energy sensor 5′-AMP-activated protein kinase (AMPK) in hepatocytes and suppression of systemic CCL2 production by peroxisome proliferator-activator receptor alpha (PPARα) reduced monocyte mobilization from the bone marrow. Importantly, while caloric restriction improves chronic inflammatory diseases, fasting did not compromise monocyte emergency mobilization during acute infectious inflammation and tissue repair. These results reveal that caloric intake and liver energy sensors dictate the blood and tissue immune tone and link dietary habits to inflammatory...
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drbstewart: Interesting @biorxivpreprint preprint alert 🚨 👨‍🍳 @MiriamMerad lab @immunodiet asked: how does caloric intake modulate inflammation? https://t.co/vR29Bg4nDb ⬇️ My journal club-esque tweetings...
opatito11: Such a pleasure to have worked with @immunodiet Dr.Jordan & @navpreet231 in this story https://t.co/LP5sSzveGs. So, so interesting monocyte modulation by fasting! @MiriamMerad @SinaiImmunol
immunodiet: How does #fasting affect the immune system? Fasting reduces circulating pro-inflammatory cells and improves inflammatory diseases, but does not increase susceptibility to infection! Our study @SinaiImmunol @MiriamMerad is online now! https://t.co/yX0PAIPI0d
PromPreprint: Dietary intake regulates the circulating inflammatory monocyte pool https://t.co/lKFw82i3lZ
Aenoreth: RT @opatito11: Such a pleasure to have worked with @immunodiet Dr.Jordan & @navpreet231 in this story https://t.co/LP5sSzveGs. So, so inte…
alagana1: RT @opatito11: Such a pleasure to have worked with @immunodiet Dr.Jordan & @navpreet231 in this story https://t.co/LP5sSzveGs. So, so inte…
TonyBurnetti: RT @PromPreprint: Dietary intake regulates the circulating inflammatory monocyte pool https://t.co/lKFw82i3lZ
AlexChudnovskiy: RT @biorxiv_immuno: Dietary intake regulates the circulating inflammatory monocyte pool https://t.co/Vu895oTK2x #biorxiv_immuno
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Sample Sizes : None.
Authors: 24
Total Words: 15067
Unqiue Words: 4394

2.008 Mikeys
#2. Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer's patch microfold cells
Nicole Y Lai, Melissa A Musser, Felipe A Pinho-Ribeiro, Pankaj Baral, Pingchuan Ma, David E Potts, Zuojia Chen, Donggi Paik, Salima Soualhi, Hailian Shi, Aditya Misra, Kaitlin Goldstein, Kisha N Sivanathan, Amanda Jacobson, Antonia Wallrapp, Valentina Lagomarsino, Vijay K Kuchroo, Roni Nowarski, Michael N Starnbach, Neeraj K Surana, Dingding An, Chuan Wu, Jun R Huh, Meenakshi Rao, Isaac M Chiu
Gut-innervating nociceptor sensory neurons respond to noxious/tissue-damaging stimuli by initiating protective responses and releasing mediators that regulate tissue inflammation, gastrointestinal secretion, and motility. The role of nociceptors in host defense against enteric pathogens is unclear. Here, we found that gut-extrinsic nociceptor neurons are critical in protecting the host against Salmonella typhimurium (STm) infection. Nociceptors responded to STm by releasing the neuropeptide calcitonin gene-related peptide (CGRP). Targeted depletion of Nav1.8 and TRPV1 neurons from gut-extrinsic dorsal root ganglia and vagal ganglia increased STm colonization, invasion, and dissemination. Nociceptors regulated the gut microbiota at homeostasis, specifically segmented filamentous bacteria (SFB) levels in the ileum, which protected against STm by colonization resistance. Nociceptors also regulated the density of microfold epithelial cells in the Peyer's patch via CGRP to limit points of entry for STm invasion into host tissues....
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biorxivpreprint: Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer's patch microfold cells https://t.co/KKYeaL5Z9k #bioRxiv
biorxiv_immuno: Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer's patch microfold cells https://t.co/sRCcnXGBxy #biorxiv_immuno
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Sample Sizes : [6, 6]
Authors: 25
Total Words: 27503
Unqiue Words: 5968

1.997 Mikeys
#3. The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Negatively Regulating Th17 Response
Gaurav Gupta, Ping Jia, Rohit Sharma, Romaniya Zayats, Sayonara M Viana, Lianyu Shan, Zhirong Mou, Viviane S Boaventura, Aldina Barral, Thomas T Murooka, Abdel Soussi-Gounni, Camila I de Oliveira, Jude Ezeh Uzonna
The long Pentraxin 3 (PTX3), a soluble pattern recognition molecule, plays a critical role in inflammation, tissue repair and wound healing. Here, we show that PTX3 regulates disease pathogenesis in cutaneous leishmaniasis (CL). PTX3 expression is increased in active skin lesions in patients and mice during CL, with higher levels being expressed in individuals with severe disease. PTX3 deficient (PTX3-/-) mice were highly resistant to L. major infection and the enhanced resistance was associated with increased IL-17 response. Neutralization of IL-17A abolished this enhanced resistance while treatment with recombinant PTX3 resulted in reduced IL-17A response and increased susceptibility to L. major infection. Naïve CD4+ T cells from PTX3-/- mice displayed increased differentiation into Th17 cells, which was reversed in the presence of recombinant PTX3. The enhanced Th17 response observed in PTX3-/- cells was associated with increased Leishmania specific IL-6 production from dendritic cells along with enhanced expression of...
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Sample Sizes : None.
Authors: 13
Total Words: 13091
Unqiue Words: 3998

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