Top 10 Biorxiv Papers Today in Epidemiology


2.002 Mikeys
#1. Identifying the diagnostic value of microRNA-421 in gastric cancer patients: a meta-analysis
Yan Miao, Ying Zhang, Lina Wang, Lihong Yin
Objectives. Emerging evidence has shown that the expression level of microRNA-421 (miR-421) was significantly different between gastric cancer (GC) patients and healthy individuals. However, the diagnostic accuracy of miR-421 in the reports remains inconsistent. This meta-analysis aims to assess the diagnostic value of miR-421 in GC detection. Methods. All related articles on miR-421 in GC diagnosis were retrieved until September 2018. The QUADAS-2 checklist was used to assess the methodological quality of each study. The diagnostic performance of miR-421 for GC were assessed by using Meta-DiSc 1.4 and STATA 14.0 statistical software. Results. A total of 172 GC patients and 154 healthy controls from three articles (four studies) were enrolled in this meta-analysis. The results of pooled sensitivity, specificity, diagnostic odds ratio (DOR) with 95% confidence interval (CI) were 0.90 (95% CI: 0.85 to 0.93), 0.83 (95% CI: 0.77 to 0.87), and 37.18 (95% CI: 8.61 to 160.49), respectively. The area under the summary receiver operating...
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MaryRuberry: Identifying the diagnostic value of microRNA-421 in gastric cancer patients: a meta-analysis #miR #Cancer https://t.co/lpJxdF9Mqv
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Authors: 4
Total Words: 3909
Unqiue Words: 1376

1.996 Mikeys
#2. Associations between impulsivity, risk behavior and HIV, HBV, HCV and syphilis seroprevalence among female prisoners in Indonesia: A cross-sectional study
Rachel Maria Arends, Erni J. Nelwan, Ratna Soediro, Reinout van Crevel, Bachti Alisjahbana, Herdiman T. Pohan, A. Katinka L. von Borries, Aart H. Schene, André J. van der Ven, Arnt F. A. Schellekens
HIV, hepatitis B and C, and syphilis share common transmission routes of which primarily unsafe sexual contact and injecting drug use are important. Impulsivity is a major factor contributing to this transmission risk behavior, however comprehensive studies within female, prison, and Asian populations are scarce. This cross-sectional study aims to delineate the contributions of different aspects of impulsivity to transmission risk behavior, among female inmates living in a prison in Jakarta (N=214). The relationships between various aspects of impulsivity, risky behavior and seropositivity were tested using analyses of variance and logistic regression analyses. Motor impulsivity was related to alcohol use, reward-related impulsivity to drug use, and cognitive/goal-directed impulsivity to sexual risk behavior. Finally, goal-directed impulsivity was also directly associated with seropositivity. Specific aspects of impulsivity are associated with different types of risky behaviors in Indonesian female prisoners, what can be relevant...
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Sample Sizes : [214, 300]
Authors: 10
Total Words: 6321
Unqiue Words: 2484

1.996 Mikeys
#3. Hashimoto’s Thyroiditis-associated Thyroid Swelling among Adolescents Presenting with Benign Goiter in Lahore, Pakistan
Syeda Nayab Batool Rizvi, Saira Shan, Shumaila Aslam, Shan Elahi, Nazsih Saleem
The aim of this study was to determine frequency of Hashimoto’s thyroiditis (HT), by determination of serum TPO-Ab titer, in 277 local goitrous adolescents (female 194, male 83) with euthyroidism or subclinical hypothyroidism. Their mean (±SD) age was 15.8 + 2.5 years with age range 10 to 19 year. Female and male adolescents were comparable in age, goiter size and serum thyroid hormone levels but mean TSH and percentage of TSH levels > 3.0 mIU/L was significantly higher in male adolescents. High serum TPO-Ab titer (> 20.0 IU/ml) or HT was detected in 38 (13.7%) patients. The incidence of HT in female (16.5%) was higher than male adolescents (7.2%) but the difference was not statistically significant (p=0.120). Similarly goiter size (palpable or visible) or patient age (below or above 16 year) has no significant effect on HT frequency. However, compared to adolescents with TSH within normal laboratory range those with TSH level above the upper normal limit (4.0 mIU/L) had significantly more frequency of HT (10.4% versus 30.4%;...
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Sample Sizes : [155, 52]
Authors: 5
Total Words: 4815
Unqiue Words: 1656

1.985 Mikeys
#4. Genetic Diversity and Coexistence of Babesia in Ticks (Acari: Ixodidae) from Northeastern
Jia-Fu Jiang, Bao-Gui Jiang, Ting-Ting Yuan, Michael E Von Fricken, Na Jia, Rui-Ruo Jiang, Yuan Zhang, Xin-Lou Li, Yuan-Chun Zheng, Qiu-Bo Huo, Yi Sun, Wu-Chun Cao
Background Babesiosis is an emerging zoonosis in humans with significant and increasing health burden in China. A few systematic reports on Babesia spp. was involved with ticks, especially in the human babesiosis endemic areas. Methods The ticks were collected from 30 individual waypoints along 2.0 km transects in two recreational forested areas in Northeastern China. Then we screened them for Babesia spp. infection by amplifying the partial 18s rRNA gene with subsequent sequencing. Multivariate logistic regression analysis was used to access the association between infections and some related risk factors. The cluster analyses were performed using SaTScan v6.0 Software for identifying the geographic cluster of the positive samples in ticks from each waypoint. Results A total of Ixodes persulcatus (n=2380) and Haemaphysalis concinna (n=461) ticks were collected. The 0.97% of I. persulcatus ticks were infected with five Babesia species, including B. bigemina (n=6), B. divergens (n=2), B. microti (n=3), B. venatorum (n=11) and one...
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Sample Sizes : [2380, 461, 6, 2, 3, 11, 6, 2, 3, 11, 8, 3]
Authors: 12
Total Words: 7668
Unqiue Words: 2736

0.0 Mikeys
#5. A systematic review of Hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: a call for urgent action
Jolynne Mokaya, Anna L McNaughton, Martin Hadley, Apsotolos Beloukas, Anna-Maria Geretti, Dominique Goedhals, Philippa C Matthews
International sustainable development goals for the elimination of viral hepatitis as a public health problem by 2030 highlight the pressing need to optimize strategies for prevention, diagnosis and treatment. Selected or transmitted resistance associated mutations (RAMs) and vaccine escape mutations (VEMs) in hepatitis B virus (HBV) may reduce the success of existing treatment and prevention strategies. These issues are particularly pressing for many settings in Africa where there is high HBV prevalence and co-endemic HIV infection, but lack of robust epidemiological data and limited education, diagnostics and clinical care. The prevalence, distribution and impact of RAMs and VEMs in these populations are neglected in the current literature. We therefore set out to assimilate data for sub-Saharan Africa through a systematic literature review and analysis of published sequence data, and present these in an on-line database (https://livedataoxford.shinyapps.io/1510659619-3Xkoe2NKkKJ7Drg/). The majority of the data were from HIV/HBV...
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Authors: 7
Total Words: 14247
Unqiue Words: 4629

0.0 Mikeys
#6. Estimating sleep parameters using an accelerometer without sleep diary
Vincent T van Hees, Severine Sabia, Samuel E Jones, Andrew R Wood, Kirstie N Anderson, Mika Kivimaki, Timothy M Frayling, Allan I Pack, Maja Bucan, Diego R Mazzotti, Phil R Gehrman, Archana Singh-Manoux, Michael N Weedon
Wrist worn raw-data accelerometers are used increasingly in large scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. Detected sleep period time window (SPT-window), was compared against sleep diary in 3752 participants (range=60-82years) and polysomnography in sleep clinic patients (N=28) and in healthy good sleepers (N=22). The SPT-window derived from the algorithm was 10.9 and 2.9 minutes longer compared with sleep diary in men and women, respectively. Mean C-statistic to detect the SPT-window compared to polysomnography was 0.86 and 0.83 in clinic-based and healthy sleepers, respectively. We demonstrated the accuracy of our algorithm to detect the SPT-window. The value of this algorithm lies in studies such as UK Biobank where a sleep diary was not used.
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Code for processing the accelerometer data from the Whitehall Study II

Repository: whitehall-acc-spt-detection-eval
User: wadpac
Language: R
Stargazers: 1
Subscribers: 1
Forks: 0
Open Issues: 0
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Sample Sizes : [28, 22, 2, 2, 3, 5, 1, 4, 1, 5, 1, 1, 0, 10, 25, 3752, 3, 27, 28, 22, 3751, 14]
Authors: 13
Total Words: 8331
Unqiue Words: 2509

0.0 Mikeys
#7. Within-host infectious disease models accommodating cellular coinfection, with an application to influenza
Katia Koelle, Alex Farrell, Christopher Brooke, Ruian Ke
Within-host models are useful tools for understanding the processes regulating viral load dynamics. While existing models have considered a wide range of within-host processes, at their core these models have shown remarkable structural similarity. Specifically, the structure of these models generally consider target cells to be either uninfected or infected, with the possibility of accommodating further resolution (for example, cells that are refractory to infection and cells that are in an eclipse phase). Recent findings, however, indicate that cellular coinfection is the norm rather than the exception for many viral infectious diseases, and that cells with high multiplicity of infection are present over at least some duration of an infection. The reality of these cellular coinfection dynamics is not accommodated in current within-host models although it may be critical for understanding within-host dynamics. This is particularly the case if multiplicity of infection impacts infected cell phenotypes such as their death rate and...
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biorxivpreprint: Within-host infectious disease models accommodating cellular coinfection, with an application to influenza https://t.co/iH5ePqprY1 #bioRxiv
LauringLab: Neat! https://t.co/hZ6apIYeRO
c__brooke: Cool work from @KatiaKoelle group developing within-host models that account for the functional consequences of MOI during influenza virus infection: https://t.co/gFcN6fXUuT
outbreaksci: Read it? Rate it. If you read "Within-host infectious disease models accommodating cellular coinfection, with an application to influenza" (https://t.co/87myH91LUO), provide an @outbreaksci rapid review here [prototype]: https://t.co/acDeHAyHI3
outbreaksci: New #influenza preprint: Within-host infectious disease models accommodating cellular coinfection, with an application to influenza https://t.co/87myH91LUO
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Authors: 4
Total Words: 7588
Unqiue Words: 2420

0.0 Mikeys
#8. Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora
Christine Tedijanto, Scott Olesen, Yonatan Grad, Marc Lipsitch
Bystander selection -- the selective pressures for resistance exerted by antibiotics on microbes that are not the target pathogen of treatment -- is critical to understanding the total impact of broad-spectrum antibiotic use on pathogenic bacterial species that are often carried asymptomatically. However, to our knowledge, this effect has never been quantified. We quantify bystander selection for resistance for a range of clinically relevant antibiotic-species pairs as the proportion of all antibiotic exposures received by a species for conditions in which that species was not the causative pathogen ('proportion of bystander exposures'). Data sources include the 2010-2011 National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey (NAMCS/NHAMCS), the Human Microbiome Project, and additional carriage and etiological data from existing literature. For outpatient prescribing in the United States, we find that this proportion over all included antibiotics is over 80% for 8 of 9 organisms of interest....
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CCDD_HSPH: Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora. Christine Tedijanto @ScottWOlesen @mlipsitch @HarvardEpi https://t.co/3TfsBbgdAF
peripatetical: Modelling suggests for most bacteria, exposure to ABx arises as consequence of treatment for another pathogen ("bystander selection") https://t.co/ppD22drfiy
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Authors: 4
Total Words: 9285
Unqiue Words: 2679

0.0 Mikeys
#9. The respiratory microbiome and susceptibility to influenza virus infection
Kyu Han Lee, Aubree Gordon, Kerby Shedden, Guillermina Kuan, Sophia Ng, Angel Balmaseda, Betsy Foxman
Influenza is a major cause of morbidity and mortality worldwide. However, vaccine effectiveness has been low to moderate in recent years and vaccine coverage remains low, especially in low- and middle-income countries. Supplementary methods of prevention should be explored to reduce the high burden of influenza. A potential target is the respiratory tract microbiome, complex microbial communities which envelop the respiratory epithelium and play an important role in shaping host immunity. Using a household transmission study, we examined whether the nose/throat microbiota was associated with influenza susceptibility among participants exposed to influenza virus in the household. Further, we characterized changes in the nose/throat microbiota to explore whether community stability was influenced by influenza virus infection. Using a generalized linear mixed effects model, we found a bacterial community type associated with decreased susceptibility to influenza. The community type was rare and transitory among young children but a...
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BrianRWasik: Here is some recent work from UMichigan researchers on effects of respiratory microbiome composition on influenza infection in a household study. #flu #virology https://t.co/ZnIDMDnhnr
hic_vac: More #microbiome research - study reveals role of respiratory microbiome in susceptibility to flu https://t.co/HoVuBRnqn0
saerobe: I am most intrigued, not with the bacterial taxa associated with influenza infection per se, but their obligate anaerobic phenotype.... The respiratory microbiome and susceptibility to influenza virus infection https://t.co/UyJUuCRklx
kirtanaramadugu: Proud of my friend @qhanlee for this awesome work! @umichsph #macepid The respiratory microbiome and susceptibility to influenza virus infection https://t.co/2GTIDJkjkw
outbreaksci: New #influenza preprint: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/KfkufT1hOZ
outbreaksci: Read it? Rate it. If you read "The respiratory microbiome and susceptibility to influenza virus infection" (https://t.co/KfkufT1hOZ), provide an @outbreaksci rapid review here [prototype]: https://t.co/acDeHAyHI3
MaryRuberry: The respiratory #microbiome and susceptibility to #influenza virus infection https://t.co/wgR4392Out
amberfarooqui: https://t.co/RFRM6Y4lRc
InfectiousDz: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
viropractor: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
ArrietaLab: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
JenneLab: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
SaubashyaSur: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
sindhuvangeti: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
sbdrysdale: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
kfibu: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
Microbe_Diva: RT @MicrobiomDigest: The respiratory microbiome and susceptibility to influenza virus infection https://t.co/QTogGKGsjm
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Authors: 7
Total Words: 9311
Unqiue Words: 3236

0.0 Mikeys
#10. Ownership, Coverage, Utilisation and Maintenance of Long-lasting insecticidal nets (LLINs) in Bamenda, Santa and Tiko Health Districts in Cameroon
Nchang Frederick Cho, Ngum Fru Paulette Cho-Azieh, Munguh Solange Fri, Menyi Blessing Cho, Kofon Patrick Jokwi, Neh Fru Celestina Tassang, Nde Peter Fon, Tassang Andrew N Tassang
ABSTRACT Introduction: The Bamenda, Santa and Tiko Health Districts are in the highest malaria transmission strata of Cameroon. The purpose of this study was to explore the indicators of ownership and utilisation as well as maintenance of long-lasting insecticidal nets (LLINs) in three health districts in Cameroon. Methods: A cross-sectional household survey involving 1,251 households was conducted in the Tiko Health District (THD) in July and June 2017 and in Bamenda and Santa Health Districts in March to May 2018. A structured questionnaire was used to collect data on LLIN ownership, utilisation and maintenance as well as demographic characteristics. Results: The average number of LLINs per household was higher in the Bamenda Health District (BHD) compared to the Tiko Health District (THD) (2.5±1.2 vs. 2.4±1.6) as well as the household ownership at least one LLIN (93.30% vs. 89.00%). The proportion of the de-facto population with universal utilisation was higher in BHD compared to THD (13.1% vs 0.2%). In multinomial regression...
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Authors: 8
Total Words: 9980
Unqiue Words: 3134

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