Top 2 Biorxiv Papers Today in Bioengineering


2.0 Mikeys
#1. Feasibility of a surface-coated lung model for the quantification of active agent deposition for preclinical studies
Philipp Doerner, Philipp M. Mueller, Jana Reiter, Martin C. Gruhlke, Alan J. Slusarenko, Wolfgang Schroeder, Michael Klaas
Multiple drug resistance (MDR) of a growing number of bacterial pathogens represents an increasing challenge in conventional curative treatments of infectious diseases. However, the development and testing of new antibiotics is associated with a high number of animal experiments. A symmetrical parametrized lung test rig allowing the exposure of air-passage surfaces to antibiotics was designed and tested to demonstrate proof-of-principle with aerosols containing allicin, which is an antimicrobial natural product from garlic. An artificial lung surface is coated with bacteria embedded in a hydrogel and growth inhibition is visualized by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), that is reduced from colourless to the dark blue formazan in the presence of metabolically active, living cells. A nebulizer is used to generate the aerosols. The results show that allicin has an antibiotic effect as an aerosol and that the deposition pattern of the active agent occurred mainly around the carinal regions. The model...
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biorxivpreprint: Feasibility of a surface-coated lung model for the quantification of active agent deposition for preclinical studies https://t.co/eVRaoer4YB #bioRxiv
biophotonicat: Feasibility of a surface-coated lung model for the quantification of active agent deposition for preclinical studies (relevance: 66%) https://t.co/PL9axNYKvr #biophotonics #biomedicaloptics
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Authors: 7
Total Words: 7504
Unqiue Words: 2326

1.997 Mikeys
#2. Distributed Biomanufacturing of Liquefied Petroleum Gas
Robin Hoeven, John Hughes, Mohamed Amer, Emilia Wojcik, Shirley Tait, Matthew Faulkner, Ian Yunus, Samantha Hardman, Linus Johannissen, Guo-Qiang Chen, Michael Smith, Patrik Jones, Helen Toogood, Nigel Scrutton
Liquefied Petroleum Gas (LPG) is a major domestic and transport fuel. Its combustion lessens NOx, greenhouse gas and particulates emissions compared to other fuels. Propane - the major constituent of LPG - is a clean, high value drop-in fuel that can help governments develop integrated fuels and energy policies with low carbon burden, providing solutions to the multi-faceted challenges of future energy supply. We show that bio-LPG (bio-propane and bio-butane) can be produced by microbial conversion of waste volatile fatty acids that can be derived from anaerobic digestion, industrial waste, or CO2 via photosynthesis. Bio-LPG production was achieved photo-catalytically, using biomass propagated from bioengineered bacteria including E. coli, Halomonas (in non-sterile seawater), and Synechocystis (photosynthetic). These fuel generation routes could be implemented rapidly in advanced and developing nations of the world to meet energy needs, global carbon reduction targets and clean air directives.
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biorxivpreprint: Distributed Biomanufacturing of Liquefied Petroleum Gas https://t.co/LT4sYFm7gR #bioRxiv
sbotlite: RT @biorxivpreprint: Distributed Biomanufacturing of Liquefied Petroleum Gas https://t.co/LT4sYFm7gR #bioRxiv
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Sample Sizes : None.
Authors: 14
Total Words: 10109
Unqiue Words: 3357

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