Top 10 Biorxiv Papers Today


2.188 Mikeys
#1. Cerebellar Purkinje cell microcircuits are essential for tremor
Amanda M Brown, Joshua J White, Meike E van der Heijden, Tao Lin, Roy V Sillitoe
Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear. Here, we found that genetically silencing cerebellar Purkinje cell activity blocked tremor in mice that were given the tremorgenic drug harmaline. We show in awake behaving mice that the onset of tremor is coincident with rhythmic Purkinje cell firing, which alters the output of their target cerebellar nuclei cells. We mimic the tremorgenic action of the drug with optogenetics and present evidence that highly patterned Purkinje cell activity drives a powerful tremor in otherwise normal mice. Modulating the altered activity with deep brain stimulation directed to the Purkinje cell output in the cerebellar nuclei reduced tremor in freely moving mice. Together, the data implicate Purkinje cell connectivity as a neural substrate for tremor and a gateway for signals that mediate the disease.
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biorxiv_neursci: Cerebellar Purkinje cell microcircuits are essential for tremor https://t.co/VnEwaJUSHr #biorxiv_neursci
biorxivpreprint: Cerebellar Purkinje cell microcircuits are essential for tremor https://t.co/eZ7nRanBRd #bioRxiv
rauf_khalid: RT @biorxiv_neursci: Cerebellar Purkinje cell microcircuits are essential for tremor https://t.co/VnEwaJUSHr #biorxiv_neursci
fcdoesneurosci: RT @biorxiv_neursci: Cerebellar Purkinje cell microcircuits are essential for tremor https://t.co/VnEwaJUSHr #biorxiv_neursci
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2.133 Mikeys
#2. Frontal and parietal neurons encode reward prediction errors in multiple reference frames
Nicholas C Foley, Michael Cohanpour, Mulugeta Semework, Sameer A Sheth, Jacqueline Gottlieb
Anticipated and experienced rewards modulate cognitive control and attention, but the mechanisms of these modulations are poorly understood. We compared neuronal responses in monkey dorsolateral prefrontal cortex and parietal area 7A, two areas strongly implicated in visual attention and working memory, related to probabilistic rewards signaled by familiar visual cues. Neurons in both areas encoded the magnitude, probability and expected value (EV) of the reward signaled by the cue. Strikingly, neurons also encoded across-trial memories of recent rewards, which, although statistically irrelevant to a trial's expectations, correlated with the monkeys' behavioral sensitivity to reward history. Finally, upon outcome delivery, neurons combined responses to the experienced outcome with renewed sensitivity to EV and reward history, allowing for population-level decoding of reward prediction errors (RPEs) relative to the trial's EV and reward history. Frontal and parietal areas explicitly encode expected and experienced outcomes and...
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biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #biorxiv_neursci
biorxivpreprint: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/NYIdOgrXpF #bioRxiv
BoozyBrain: RT @biorxivpreprint: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/NYIdOgrXpF #bi…
DrJKhokhar: RT @biorxivpreprint: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/NYIdOgrXpF #bi…
PhilCorlett1: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
DVSneuro: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
whatnowning: RT @biorxivpreprint: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/NYIdOgrXpF #bi…
BlakeP_Neuro: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
bdean_: RT @biorxivpreprint: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/NYIdOgrXpF #bi…
estef_azevedo: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
NeuroLuyckx: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
ErdemPulcu: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
ml_unam: RT @biorxiv_neursci: Frontal and parietal neurons encode reward prediction errors in multiple reference frames https://t.co/feBKZQJmOU #bi…
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2.111 Mikeys
#3. Efferent Modulation Of Spontaneous Lateral Line Activity During And After Zebrafish Motor Commands
Elias T Lunsford, Dimitri A Skandalis, James C Liao
Accurate sensory processing during movement requires the animal to distinguish between external (exafferent) and self-generated (reafferent) stimuli to maintain sensitivity to biologically relevant cues. The lateral line system in fishes is a mechanosensory organ that experiences reafferent sensory feedback via detection of fluid motion relative to the body generated during behaviors such as swimming. For the first time in larval zebrafish ( Danio rerio ), we employed simultaneous recordings of lateral line and motor activity to reveal the activity of afferent neurons arising from endogenous feedback from hindbrain efferent neurons during locomotion. Frequency of spontaneous spiking in posterior lateral line afferent neurons decreased during motor activity and was absent for more than half of swimming trials. Targeted photoablation of efferent neurons abolished the afferent inhibition that was correlated to swimming, indicating that inhibitory efferent neurons are necessary for modulating lateral line sensitivity during...
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biorxiv_neursci: Efferent Modulation Of Spontaneous Lateral Line Activity During And After Zebrafish Motor Commands https://t.co/TyyifS7IBF #biorxiv_neursci
biorxivpreprint: Efferent Modulation Of Spontaneous Lateral Line Activity During And After Zebrafish Motor Commands https://t.co/sOsxREzjei #bioRxiv
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2.061 Mikeys
#4. No evidence for an S cone contribution to the human circadian response to light
Manuel Spitschan, Rafael Lazar, Ebru Yetik, Christian Cajochen
Exposure to even moderately bright, short-wavelength light in the evening can strongly suppress the production of melatonin and can delay our circadian rhythm. These effects are mediated by the retinohypothalamic pathway, connecting a subset of retinal ganglion cells to the circadian pacemaker in the suprachiasmatic nucleus (SCN) in the brain. These retinal ganglion cells directly express the photosensitive protein melanopsin, rendering them intrinsically photosensitive (ipRGCs). But ipRGCs also receive input from the classical photoreceptors -- the cones and rods. Here, we examined whether the short-wavelength-sensitive (S) cones contribute to circadian photoreception by using lights which differed exclusively in the amount of S cone excitation by almost two orders of magnitude (ratio 1:83), but not in the excitation of long-wavelength-sensitive (L) and medium-wavelength-sensitive (M) cones, rods, and melanopsin. We find no evidence for a role of S cones in the acute alerting and melatonin supressing response to evening light...
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biorxiv_neursci: No evidence for an S cone contribution to the human circadian response to light https://t.co/nvHdu5smWg #biorxiv_neursci
biorxivpreprint: No evidence for an S cone contribution to the human circadian response to light https://t.co/RjRR0FC6kk #bioRxiv
raulclima: RT @biorxiv_neursci: No evidence for an S cone contribution to the human circadian response to light https://t.co/nvHdu5smWg #biorxiv_neur…
RetinaGeek: RT @biorxiv_neursci: No evidence for an S cone contribution to the human circadian response to light https://t.co/nvHdu5smWg #biorxiv_neur…
seematrivedy: RT @biorxivpreprint: No evidence for an S cone contribution to the human circadian response to light https://t.co/RjRR0FC6kk #bioRxiv
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2.021 Mikeys
#5. A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety
Qian Xiao, Xinyi Zhou, Pengfei Wei, Li Xie, Yaning Han, Bifeng Wu, Jie Wang, Aoling Cai, Fuqiang Xu, Yi Lu, Jie Tu, Liping Wang
The prevailing view is that parvalbumin (PV) interneurons play modulatory roles in emotional response through local medium spiny projection neurons (MSNs). Here, we show that PV activity within the nucleus accumbens shell (sNAc) is required for producing anxiety-related avoidance when mice are under anxiogenic situations; sNAcPV neurons exhibited high excitability in chronically stressed mice model, which generated excessive maladaptive avoidance behavior in an anxiogenic context. We also discovered a novel GABAergic projections from the anterior dorsal bed nuclei of stria terminalis (adBNST) to sNAcPV neurons; optogenetic activation of these afferent terminals in sNAc produced an anxiolytic effect via GABA transmission. Next, we further demonstrated that chronic stressors attenuated the inhibitory synaptic transmission at adBNSTGABA-sNAcPV synapses, which in turn explains the hyperexcitability of sNAcPV neurons on stressed models; therefore, activation of these GABAergic afferents in sNAc rescued the excessive avoidance behavior...
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rauf_khalid: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
FlyBottleEscape: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
bogglerapture: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
perothwell: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
BrianMathur1: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
MicTott: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
WickmanLab: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
marcpisansky: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
ATzilivaki: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
dan_ai_lama: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
Coka_Hoo: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
sudo_BreeB: RT @biorxiv_neursci: A new GABAergic projection from the BNST onto accumbal parvalbumin neurons controls anxiety https://t.co/qlGhkfud7P #…
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Authors: 12
Total Words: 16494
Unqiue Words: 4185

2.019 Mikeys
#6. An integrative assessment of aquatic ecosystem services based on guideline thresholds
Nicolas Fortin St-Gelais, Jean-Francois Lapierre, Robert Siron, Roxane Maranger
Ecologists typically associate water quality with trophic status where oligotrophic ecosystems have excellent water quality and presumably provide more aquatic ecosystem services. However water quality is perceived differently among worldviews. Aquatic ecosystem service provisioning to the public health and agriculture sectors is determined using specific guidelines. But are these guidelines related to trophic status? Here, we developed an integrative ecosystem service framework using guideline thresholds for drinking, swimming, irrigation, suitability for livestock and aquatic wildlife in canadian rivers of varying trophic status. Drinkability was the most sensitive ecosystem service, met in 37% of cases, whereas livestock was the least, provided in 99%. Trophic status is a fair proxy for ecosystem services limited by fecal contamination as nutrients are related to human and animal populations, but not to those limited by metals. Using quantitative thresholds to assess the safe provisioning of multiple ecosystem services provides...
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biorxivpreprint: An integrative assessment of aquatic ecosystem services based on guideline thresholds https://t.co/nqeotxss6K #bioRxiv
biorxiv_ecology: An integrative assessment of aquatic ecosystem services based on guideline thresholds https://t.co/uoHh5FmmAG #biorxiv_ecology
ProfColinBean: RT @biorxiv_ecology: An integrative assessment of aquatic ecosystem services based on guideline thresholds https://t.co/uoHh5FmmAG #biorxi…
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Authors: 4
Total Words: 6816
Unqiue Words: 1839

2.016 Mikeys
#7. Complex eukaryotic-like actin regulation systems from Asgard archaea
Caner Akil, Linh T Tran, Magali Orhant-Prioux, Yohendran Baskaran, Edward Manser, Laurent Blanchoin, Robert C Robinson
Asgard archaea genomes contain potential eukaryotic-like genes that provide intriguing insight for the evolution of eukaryotes. The actin polymerization/depolymerization cycle is critical for providing force and structure for a variety of processes in eukaryotes, including membrane remodelling. Here, we identify actin filament severing, capping, annealing and bundling, and monomer sequestration activities by gelsolin proteins from Thorarchaeota (Thor), which complete a eukaryote-like actin depolymerization cycle. Thor gelsolins are comprised of one or two copies of the prototypical gelsolin domain and appear to be a record of an initial pre-eukaryotic gene duplication event, since eukaryotic gelsolins are generally comprised of three to six domains. X-ray crystal structure determination of these proteins in complex with mammalian actin revealed similar interactions to the first domain of human gelsolin. Asgard two-domain, but not one-domain, gelsolins contain calcium-binding sites, which is manifested in calcium-controlled...
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BiologiaNhid: La Biologia dels arqueus està on fire! 🔥🔥 Un altre article a Biorxive parlant dels mecanismes de remodelació de la membrana...#BiologiaNHiD https://t.co/qernO4Ixrt
archaeal: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
BejaLab: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
Dey_Gautam: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
mehrshmali: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
MFSeidl: RT @biorxivpreprint: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/6yx02IGo0S #bioRxiv
EvolPaper: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
ElectricBiome: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
tarnotron: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
jspathmanathan: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
rcooperbaer: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
mpfrancino: RT @biorxiv_evobio: Complex eukaryotic-like actin regulation systems from Asgard archaea https://t.co/RKIXWwmmiM #biorxiv_evobio
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2.016 Mikeys
#8. Disulfide disruption reverses mucus dysfunction in allergic airway disease
Leslie E Morgan, Siddharth K Shenoy, Dorota Raclawska, Nkechinyere A Emezienna, Vanessa L Richardson, Naoko Hara, Anna Q Harder, Hassan M El-Batal, Chelsea M Magin, Diane E. Grove Villalon, Gregg Duncan, Justin S Hanes, Jung Soo Suk, David J Thornton, Fernando Holguin, William J Janssen, William R Thelin, Christopher M Evans
Airway mucus is essential for healthy lung defense, but excessive mucus in asthma obstructs airflow, leading to severe and potentially fatal outcomes. Current asthma therapies reduce allergic inflammation and relax airway smooth muscle, but treatments are often inadequate due to their minimal effects on mucus obstruction. The lack of efficacious mucus-targeted treatments stems from a poor understanding of healthy mucus function and pathological mucus dysfunction at a molecular level. The chief macromolecules in mucus, polymeric mucins, are massive glycoproteins whose sizes and biophysical properties are dictated in part by covalent disulfide bonds that link mucin molecules into assemblies of 10 or more subunits. Once secreted, mucin glycopolymers can aggregate to form plugs that block airflow. Here we show that reducing mucin disulfide bonds depolymerizes mucus in human asthma and reverses pathological effects of mucus hypersecretion in a mouse allergic asthma model. In mice challenged with a fungal allergen, inhaled mucolytic...
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biorxivpreprint: Disulfide disruption reverses mucus dysfunction in allergic airway disease https://t.co/72TFqZsCQy #bioRxiv
biorxiv_physio: Disulfide disruption reverses mucus dysfunction in allergic airway disease https://t.co/lMBbpnoHrI #biorxiv_physio
F19_joyner: RT @biorxivpreprint: Disulfide disruption reverses mucus dysfunction in allergic airway disease https://t.co/72TFqZsCQy #bioRxiv
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2.016 Mikeys
#9. Taxonomically and metabolically distinct microbial communities with depth and across a hillslope to riparian zone transect
Adi Lavy, Paula B. Matheus Carnevali, Ray Keren, Markus Bill, Jiamin Wan, Tetsu K. Tokunaga, Kenneth H. Williams, Susan S. Hubbard, Jillian F. Banfield
Watersheds are important for supplying fresh water, the quality of which depends on complex interplay involving physical, chemical and biological processes. As water percolates through the soil and underlying weathering rock en route to the river corridor, microorganisms mediate key geochemical transformations, yet the distribution and functional capacities of subsurface microbial communities remain little understood. Here, we used genome resolved metagenomics to study microbial communities during late summer along a 230 m hillslope meadow to floodplain transect within the mountainous East-River watershed, Colorado. We found very limited strain/species overlap at different depths below the ground surface and at different distances along the hillslope, possibly due to restricted hydraulic connectivity after early stages of snowmelt, and show that communities are largely distinct in their metabolic capacities. Both proximity to the river and to the underlying Mancos shale apparently control species distribution and metabolic...
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biorxivpreprint: Taxonomically and metabolically distinct microbial communities with depth and across a hillslope to riparian zone transect https://t.co/pmttRhwlsY #bioRxiv
biorxiv_bioinfo: Taxonomically and metabolically distinct microbial communities with depth and across a hillslope to riparian zone transect https://t.co/od8aCqabCK #biorxiv_bioinfo
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2.014 Mikeys
#10. Kinomorphs: Shape-shifting tissues for developmental engineering
John M. Viola, Catherine M. Porter, Ananya Gupta, Mariia Alibekova, Louis S. Prahl, Alex James Hughes
Current methods for building tissues usually start with a non-biological blueprint, or rely on self-organization, which does not extend to organ-scales. This has limited the construction of large tissues that simultaneously encode fine-scale cell organization. Here we bridge scales by mimicking developmental dynamics using "kinomorphs", tissue scaffolds that undergo globally programmed shape and density changes to trigger local self-organization of cells in many locations at once. In this first report, we focus on mimicking the extracellular matrix (ECM) compaction and division into leaflets that occurs in kidney collecting duct development. We start by creating single-cell resolution cell patterns in ECM-mimetic hydrogels that are >10x larger than previously described, by leveraging photo-lithographic technology. These patterns are designed to mimic the branch geometry of the embryonic kidney collecting duct tree. We then predict the shape dynamics of kinomorphs driven by cell contractility-based compaction of the ECM using...
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biorxivpreprint: Kinomorphs: Shape-shifting tissues for developmental engineering https://t.co/H5PtFCIpgx #bioRxiv
HughesLabPenn: We recently submitted our first #bioRxiv pre-print! A true team effort that explores the effect of engineered shape dynamics in extracellular matrix (ECM) on epithelial tubule morphogenesis. We build self-folding "kinomorph" materials to study this. https://t.co/CbUCbRvz8b https://t.co/jwmf0mQbKP
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Assert is a website where the best academic papers on arXiv (computer science, math, physics), bioRxiv (biology), BITSS (reproducibility), EarthArXiv (earth science), engrXiv (engineering), LawArXiv (law), PsyArXiv (psychology), SocArXiv (social science), and SportRxiv (sport research) bubble to the top each day.

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